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Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss

BACKGROUND: Although mRNA dysregulation can induce changes in mesenchymal stem cell (MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences MSC differentiation potential remain understudied. PUMILIO2 (PUM2) represses translation by binding target mRNAs in a sequence-spe...

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Detalles Bibliográficos
Autores principales:	Yoon, Dong Suk, Choi, Yoorim, Lee, Kyoung-Mi, Ko, Eun Ae, Kim, Eun-Ji, Park, Kwang Hwan, Lee, Jin Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122812/ https://www.ncbi.nlm.nih.gov/pubmed/37088847 http://dx.doi.org/10.1186/s12929-023-00920-8

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