Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study

OBJECTIVES: Methotrexate (MTX) is associated with extensive side effects, including myelosuppression, interstitial pneumonia, and infection. It is, therefore, critical to establish whether its administration is required after achieving remission with tocilizumab (TCZ) and MTX combination therapy in...

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Detalles Bibliográficos
Autores principales: Miyata, Masayuki, Hirabayashi, Yasuhiko, Munakata, Yasuhiko, Urata, Yukitomo, Saito, Koichi, Okuno, Hiroshi, Yoshida, Masaaki, Kodera, Takao, Watanabe, Ryu, Miyamoto, Seiya, Ishii, Tomonori, Nakazawa, Shigeshi, Takemori, Hiromitsu, Ando, Takanobu, Kanno, Takashi, Komagamine, Masataka, Kato, Ichiro, Takahashi, Yuichi, Komatsuda, Atsushi, Endo, Kojiro, Murai, Chihiro, Takakubo, Yuya, Miura, Takao, Sato, Yukio, Ichikawa, Kazunobu, Konta, Tsuneo, Chiba, Noriyuki, Muryoi, Tai, Kobayashi, Hiroko, Fujii, Hiroshi, Sekiguchi, Yukio, Hatakeyama, Akira, Ogura, Ken, Sakuraba, Hirotake, Asano, Tomoyuki, Kanazawa, Hiroshi, Suzuki, Eiji, Takasaki, Satoshi, Asakura, Kenichi, Suzuki, Yoko, Takagi, Michiaki, Nakayama, Takahiro, Watanabe, Hiroshi, Miura, Keiki, Mori, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Fukushima Society of Medical Science 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122970/
https://www.ncbi.nlm.nih.gov/pubmed/36990790
http://dx.doi.org/10.5387/fms.2022-06

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