Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic

Our case report highlights the importance of understanding various mechanisms of an atrioventricular block (AVB) and recognizing potential iatrogenic culprits. Despite the prevalent use of second-generation antipsychotics and the growing popularity of long-acting formulations, it is not routinely re...

Descripción completa

Detalles Bibliográficos
Autores principales: Harrisingh, Kamahl, Cu, Cameron, Le, Marjolein Le, Benhayon, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123026/
https://www.ncbi.nlm.nih.gov/pubmed/37101998
http://dx.doi.org/10.7759/cureus.36650
_version_ 1785029610523590656
author Harrisingh, Kamahl
Cu, Cameron
Le, Marjolein Le
Benhayon, Daniel
author_facet Harrisingh, Kamahl
Cu, Cameron
Le, Marjolein Le
Benhayon, Daniel
author_sort Harrisingh, Kamahl
collection PubMed
description Our case report highlights the importance of understanding various mechanisms of an atrioventricular block (AVB) and recognizing potential iatrogenic culprits. Despite the prevalent use of second-generation antipsychotics and the growing popularity of long-acting formulations, it is not routinely recognized as a cause for AVB. Second-generation antipsychotics such as risperidone have a dose-dependent pro-arrhythmic effect and are known to cause first-degree AVB. Our case presents an opportunity to recognize an unappreciated cause for AVB and switch to safer alternatives. In the era of long-acting injectables, it is important to monitor for these effects prior to escalating doses and risking high-degree AVB.
format Online
Article
Text
id pubmed-10123026
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-101230262023-04-25 Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic Harrisingh, Kamahl Cu, Cameron Le, Marjolein Le Benhayon, Daniel Cureus Cardiology Our case report highlights the importance of understanding various mechanisms of an atrioventricular block (AVB) and recognizing potential iatrogenic culprits. Despite the prevalent use of second-generation antipsychotics and the growing popularity of long-acting formulations, it is not routinely recognized as a cause for AVB. Second-generation antipsychotics such as risperidone have a dose-dependent pro-arrhythmic effect and are known to cause first-degree AVB. Our case presents an opportunity to recognize an unappreciated cause for AVB and switch to safer alternatives. In the era of long-acting injectables, it is important to monitor for these effects prior to escalating doses and risking high-degree AVB. Cureus 2023-03-24 /pmc/articles/PMC10123026/ /pubmed/37101998 http://dx.doi.org/10.7759/cureus.36650 Text en Copyright © 2023, Harrisingh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Harrisingh, Kamahl
Cu, Cameron
Le, Marjolein Le
Benhayon, Daniel
Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title_full Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title_fullStr Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title_full_unstemmed Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title_short Teetering on the Edge: Second-Degree Atrioventricular Block Following Long-Acting Second-Generation Antipsychotic
title_sort teetering on the edge: second-degree atrioventricular block following long-acting second-generation antipsychotic
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123026/
https://www.ncbi.nlm.nih.gov/pubmed/37101998
http://dx.doi.org/10.7759/cureus.36650
work_keys_str_mv AT harrisinghkamahl teeteringontheedgeseconddegreeatrioventricularblockfollowinglongactingsecondgenerationantipsychotic
AT cucameron teeteringontheedgeseconddegreeatrioventricularblockfollowinglongactingsecondgenerationantipsychotic
AT lemarjoleinle teeteringontheedgeseconddegreeatrioventricularblockfollowinglongactingsecondgenerationantipsychotic
AT benhayondaniel teeteringontheedgeseconddegreeatrioventricularblockfollowinglongactingsecondgenerationantipsychotic