Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype

Pre- and post-term children show increased autism risk. Little is known about gestational age (GA) prevalence among autistic children, and their respective autism phenotype. We compared prevalence of pre-, full- and post-term birth between a population-derived sample of N = 606 (137 females, 22.61%)...

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Autores principales: Martini, Miriam I., Merkelbach, Inge, Begeer, Sander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123031/
https://www.ncbi.nlm.nih.gov/pubmed/35129797
http://dx.doi.org/10.1007/s10803-022-05466-6
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author Martini, Miriam I.
Merkelbach, Inge
Begeer, Sander
author_facet Martini, Miriam I.
Merkelbach, Inge
Begeer, Sander
author_sort Martini, Miriam I.
collection PubMed
description Pre- and post-term children show increased autism risk. Little is known about gestational age (GA) prevalence among autistic children, and their respective autism phenotype. We compared prevalence of pre-, full- and post-term birth between a population-derived sample of N = 606 (137 females, 22.61%) autistic children and adolescents (mean age = 14.01, SD = 3.63, range 3–24) from the Netherlands Autism Register, and matched controls from the Dutch birth register. Autism phenotype and comorbid symptoms were assessed with the AQ-short and SDQ questionnaires. Using logistic regression, we found higher prevalence of pre- and post-term birth among autistic individuals but no phenotypical differences across GA groups. Autism risk was particularly elevated for post-term children, highlighting the need for closer investigation of autism on the whole GA range.
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spelling pubmed-101230312023-04-25 Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype Martini, Miriam I. Merkelbach, Inge Begeer, Sander J Autism Dev Disord Original Paper Pre- and post-term children show increased autism risk. Little is known about gestational age (GA) prevalence among autistic children, and their respective autism phenotype. We compared prevalence of pre-, full- and post-term birth between a population-derived sample of N = 606 (137 females, 22.61%) autistic children and adolescents (mean age = 14.01, SD = 3.63, range 3–24) from the Netherlands Autism Register, and matched controls from the Dutch birth register. Autism phenotype and comorbid symptoms were assessed with the AQ-short and SDQ questionnaires. Using logistic regression, we found higher prevalence of pre- and post-term birth among autistic individuals but no phenotypical differences across GA groups. Autism risk was particularly elevated for post-term children, highlighting the need for closer investigation of autism on the whole GA range. Springer US 2022-02-07 2023 /pmc/articles/PMC10123031/ /pubmed/35129797 http://dx.doi.org/10.1007/s10803-022-05466-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Martini, Miriam I.
Merkelbach, Inge
Begeer, Sander
Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title_full Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title_fullStr Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title_full_unstemmed Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title_short Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype
title_sort gestational age in autistic children and adolescents: prevalence and effects on autism phenotype
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123031/
https://www.ncbi.nlm.nih.gov/pubmed/35129797
http://dx.doi.org/10.1007/s10803-022-05466-6
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