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Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

TP53-mutant acute myeloid leukemia (AML) respond poorly to currently available treatments, including venetoclax-based drug combinations and pose a major therapeutic challenge. Analyses of RNA sequencing and reverse phase protein array datasets revealed significantly lower BAX RNA and protein levels...

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Detalles Bibliográficos
Autores principales:	Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Ayoub, Edward, Ostermann, Lauren B., Huang, Xuelin, Loghavi, Sanam, Boettcher, Steffen, Nishida, Yuki, Ruvolo, Vivian, Hughes, Paul E., Morrow, Phuong K., Haferlach, Torsten, Kornblau, Steven, Muftuoglu, Muharrem, Andreeff, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123065/ https://www.ncbi.nlm.nih.gov/pubmed/37088806 http://dx.doi.org/10.1038/s41408-023-00830-w

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