Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing

A major challenge confronting the clinical application of site-directed RNA editing (SDRE) is the design of small guide RNAs (gRNAs) that can drive efficient editing. Although many gRNA designs have effectively recruited endogenous Adenosine Deaminases that Act on RNA (ADARs), most of them exceed th...

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Detalles Bibliográficos
Autores principales: Diaz Quiroz, Juan Felipe, Ojha, Namrata, Shayhidin, Elnur E, De Silva, Dasuni, Dabney, Jesse, Lancaster, Amy, Coull, James, Milstein, Stuart, Fraley, Andrew W, Brown, Christopher R, Rosenthal, Joshua J C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123091/
https://www.ncbi.nlm.nih.gov/pubmed/36840708
http://dx.doi.org/10.1093/nar/gkad098

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