Heavy metal ions exchange driven protein phosphorylation cascade functions in genomic instability in spermatocytes and male infertility

DNA double-strand breaks (DSBs) are functionally linked to genomic instability in spermatocytes and to male infertility. The heavy metal cadmium (Cd) is known to induce DNA damage in spermatocytes by unknown mechanisms. Here, we showed that Cd ions impaired the canonical non-homologous end-joining (...

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Detalles Bibliográficos
Autores principales: Li, Ren-Yan, Yang, Dan, He, Yan-Ji, Zhou, Yong, Li, Cheng-Cheng, Li, Lian-Bing, Liao, Ming-Xing, Deng, Zhong-Liang, Zhao, Le-Tian, Zhang, Tian-Feng, Luo, Yong, Wang, Ying-Xiong, Gao, Yan-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123093/
https://www.ncbi.nlm.nih.gov/pubmed/36869674
http://dx.doi.org/10.1093/nar/gkad128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123093/
https://www.ncbi.nlm.nih.gov/pubmed/36869674
http://dx.doi.org/10.1093/nar/gkad128

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