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MIRELLA: a mathematical model explains the effect of microRNA-mediated synthetic genes regulation on intracellular resource allocation

Competition for intracellular resources, also known as gene expression burden, induces coupling between independently co-expressed genes, a detrimental effect on predictability and reliability of gene circuits in mammalian cells. We recently showed that microRNA (miRNA)-mediated target downregulatio...

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Detalles Bibliográficos
Autores principales:	Cella, Federica, Perrino, Giansimone, Tedeschi, Fabiana, Viero, Gabriella, Bosia, Carla, Stan, Guy-Bart, Siciliano, Velia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123119/ https://www.ncbi.nlm.nih.gov/pubmed/36912077 http://dx.doi.org/10.1093/nar/gkad151

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