PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

We have uncovered a role for the promyelocytic leukemia (PML) gene and novel PML-like DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 (L1) retrotransposition in jawed vertebrates. Although the mammalian PML protein forms nuclear bodies, we found that the s...

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Detalles Bibliográficos
Autores principales: Mathavarajah, Sabateeshan, Vergunst, Kathleen L, Habib, Elias B, Williams, Shelby K, He, Raymond, Maliougina, Maria, Park, Mika, Salsman, Jayme, Roy, Stéphane, Braasch, Ingo, Roger, Andrew J, Langelaan, David N, Dellaire, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123124/
https://www.ncbi.nlm.nih.gov/pubmed/36912092
http://dx.doi.org/10.1093/nar/gkad152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123124/
https://www.ncbi.nlm.nih.gov/pubmed/36912092
http://dx.doi.org/10.1093/nar/gkad152

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