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A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review

Calciphylaxis is an infrequent yet lethal disease often associated with end-stage kidney disease (ESKD). The most common sites include proximal and distal extremities and the trunk, with few reported in the penis and very few as gastrointestinal (GI) disease. We report a case of systemic calciphylax...

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Autores principales: Chinnappan, Justine, Aguirre, Jesus, Marcus, Huda, Azher, Qazi, Bachuwa, Ghassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123329/
https://www.ncbi.nlm.nih.gov/pubmed/37101995
http://dx.doi.org/10.7759/cureus.36641
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author Chinnappan, Justine
Aguirre, Jesus
Marcus, Huda
Azher, Qazi
Bachuwa, Ghassan
author_facet Chinnappan, Justine
Aguirre, Jesus
Marcus, Huda
Azher, Qazi
Bachuwa, Ghassan
author_sort Chinnappan, Justine
collection PubMed
description Calciphylaxis is an infrequent yet lethal disease often associated with end-stage kidney disease (ESKD). The most common sites include proximal and distal extremities and the trunk, with few reported in the penis and very few as gastrointestinal (GI) disease. We report a case of systemic calciphylaxis in a middle-aged male, presenting with a colostomy leak and parastomal abscess. Workup revealed severe calcification of the intestinal arteries and ischemic colon necrosis. The patient underwent colectomy, antibiotic therapy, regular hemodialysis (HD), and sodium thiosulphate infusion with clinical stability. Histopathology of the colon revealed ischemic necrosis and pericolonic vessel calcification suggestive of calciphylaxis. It is an important differential to be considered in patients with risk factors presenting with symptoms of gastrointestinal hemorrhage and necrosis with perforation.
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spelling pubmed-101233292023-04-25 A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review Chinnappan, Justine Aguirre, Jesus Marcus, Huda Azher, Qazi Bachuwa, Ghassan Cureus Gastroenterology Calciphylaxis is an infrequent yet lethal disease often associated with end-stage kidney disease (ESKD). The most common sites include proximal and distal extremities and the trunk, with few reported in the penis and very few as gastrointestinal (GI) disease. We report a case of systemic calciphylaxis in a middle-aged male, presenting with a colostomy leak and parastomal abscess. Workup revealed severe calcification of the intestinal arteries and ischemic colon necrosis. The patient underwent colectomy, antibiotic therapy, regular hemodialysis (HD), and sodium thiosulphate infusion with clinical stability. Histopathology of the colon revealed ischemic necrosis and pericolonic vessel calcification suggestive of calciphylaxis. It is an important differential to be considered in patients with risk factors presenting with symptoms of gastrointestinal hemorrhage and necrosis with perforation. Cureus 2023-03-24 /pmc/articles/PMC10123329/ /pubmed/37101995 http://dx.doi.org/10.7759/cureus.36641 Text en Copyright © 2023, Chinnappan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Chinnappan, Justine
Aguirre, Jesus
Marcus, Huda
Azher, Qazi
Bachuwa, Ghassan
A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title_full A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title_fullStr A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title_full_unstemmed A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title_short A Fatal Case of Systemic Calciphylaxis in the Gastrointestinal Tract: A Case Report and Literature Review
title_sort fatal case of systemic calciphylaxis in the gastrointestinal tract: a case report and literature review
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123329/
https://www.ncbi.nlm.nih.gov/pubmed/37101995
http://dx.doi.org/10.7759/cureus.36641
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