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Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study

BACKGROUND: The Democratic Republic of the Congo (DRC) is one of the countries with the highest rotavirus mortality rate in the world. The aim of this study was to describe the clinical features of rotavirus infection after the introduction of rotavirus vaccination of children in the city of Kisanga...

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Autores principales: Gbebangi-Manzemu, Didier, Kampunzu, Véronique Muyobela, Vanzwa, Hortense Malikidogo, Mumbere, Mupenzi, Bukaka, Gaspard Mande, Likele, Bibi Batoko, Kasai, Emmanuel Tebandite, Mukinayi, Benoit Mbiya, Tonen-Wolyec, Serge, Dauly, Nestor Ngbonda, Alworong’a Opara, Jean Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123467/
https://www.ncbi.nlm.nih.gov/pubmed/37095482
http://dx.doi.org/10.1186/s12887-023-04022-0
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author Gbebangi-Manzemu, Didier
Kampunzu, Véronique Muyobela
Vanzwa, Hortense Malikidogo
Mumbere, Mupenzi
Bukaka, Gaspard Mande
Likele, Bibi Batoko
Kasai, Emmanuel Tebandite
Mukinayi, Benoit Mbiya
Tonen-Wolyec, Serge
Dauly, Nestor Ngbonda
Alworong’a Opara, Jean Pierre
author_facet Gbebangi-Manzemu, Didier
Kampunzu, Véronique Muyobela
Vanzwa, Hortense Malikidogo
Mumbere, Mupenzi
Bukaka, Gaspard Mande
Likele, Bibi Batoko
Kasai, Emmanuel Tebandite
Mukinayi, Benoit Mbiya
Tonen-Wolyec, Serge
Dauly, Nestor Ngbonda
Alworong’a Opara, Jean Pierre
author_sort Gbebangi-Manzemu, Didier
collection PubMed
description BACKGROUND: The Democratic Republic of the Congo (DRC) is one of the countries with the highest rotavirus mortality rate in the world. The aim of this study was to describe the clinical features of rotavirus infection after the introduction of rotavirus vaccination of children in the city of Kisangani, DRC. METHODS: We conducted a cross-sectional study of acute diarrhoea in children under 5 years of age admitted to 4 hospitals in Kisangani, DRC. Rotavirus was detected in children’s stools by an immuno-chromatographic antigenic rapid diagnostic test. RESULTS: A total of 165 children under 5 years of age were included in the study. We obtained 59 cases of rotavirus infection, or 36% CI95 [27, 45]. The majority of children with rotavirus infection were unvaccinated (36 cases) and had watery diarrhoea (47 cases), of high frequency per day/per admission 9.6 ± 3.4 and accompanied by severe dehydration (30 cases). A statistically significant difference in mean Vesikari score was observed between unvaccinated and vaccinated children (12.7 vs 10.7 p-value 0.024). CONCLUSION: Rotavirus infection in hospitalized children under 5 years of age is characterized by a severe clinical manifestation. Epidemiological surveillance is needed to identify risk factors associated with the infection.
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spelling pubmed-101234672023-04-25 Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study Gbebangi-Manzemu, Didier Kampunzu, Véronique Muyobela Vanzwa, Hortense Malikidogo Mumbere, Mupenzi Bukaka, Gaspard Mande Likele, Bibi Batoko Kasai, Emmanuel Tebandite Mukinayi, Benoit Mbiya Tonen-Wolyec, Serge Dauly, Nestor Ngbonda Alworong’a Opara, Jean Pierre BMC Pediatr Research BACKGROUND: The Democratic Republic of the Congo (DRC) is one of the countries with the highest rotavirus mortality rate in the world. The aim of this study was to describe the clinical features of rotavirus infection after the introduction of rotavirus vaccination of children in the city of Kisangani, DRC. METHODS: We conducted a cross-sectional study of acute diarrhoea in children under 5 years of age admitted to 4 hospitals in Kisangani, DRC. Rotavirus was detected in children’s stools by an immuno-chromatographic antigenic rapid diagnostic test. RESULTS: A total of 165 children under 5 years of age were included in the study. We obtained 59 cases of rotavirus infection, or 36% CI95 [27, 45]. The majority of children with rotavirus infection were unvaccinated (36 cases) and had watery diarrhoea (47 cases), of high frequency per day/per admission 9.6 ± 3.4 and accompanied by severe dehydration (30 cases). A statistically significant difference in mean Vesikari score was observed between unvaccinated and vaccinated children (12.7 vs 10.7 p-value 0.024). CONCLUSION: Rotavirus infection in hospitalized children under 5 years of age is characterized by a severe clinical manifestation. Epidemiological surveillance is needed to identify risk factors associated with the infection. BioMed Central 2023-04-24 /pmc/articles/PMC10123467/ /pubmed/37095482 http://dx.doi.org/10.1186/s12887-023-04022-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Gbebangi-Manzemu, Didier
Kampunzu, Véronique Muyobela
Vanzwa, Hortense Malikidogo
Mumbere, Mupenzi
Bukaka, Gaspard Mande
Likele, Bibi Batoko
Kasai, Emmanuel Tebandite
Mukinayi, Benoit Mbiya
Tonen-Wolyec, Serge
Dauly, Nestor Ngbonda
Alworong’a Opara, Jean Pierre
Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title_full Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title_fullStr Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title_full_unstemmed Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title_short Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study
title_sort clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in kisangani, drc, after the introduction of the rotavirus vaccine, a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123467/
https://www.ncbi.nlm.nih.gov/pubmed/37095482
http://dx.doi.org/10.1186/s12887-023-04022-0
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