The rationale and study design of two phase II trials examining the effects of BI 685509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis

BACKGROUND: Clinically significant portal hypertension (CSPH) drives cirrhosis-related complications (i.e. hepatic decompensation). Impaired nitric oxide (NO) bioavailability promotes sinusoidal vasoconstriction, which is the initial pathomechanism of CSPH development. Activation of soluble guanylyl...

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Detalles Bibliográficos
Autores principales: Reiberger, Thomas, Berzigotti, Annalisa, Trebicka, Jonel, Ertle, Judith, Gashaw, Isabella, Swallow, Ros, Tomisser, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123479/
https://www.ncbi.nlm.nih.gov/pubmed/37095557
http://dx.doi.org/10.1186/s13063-023-07291-3

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