Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia

Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administrat...

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Detalles Bibliográficos
Autores principales: Shiroshita, Kohei, Okayama, Mikio, Soma, Hiroki, Sato, Yuki, Hayashi, Hiroyoshi, Shiozawa, Yuka, Okamoto, Shinichiro, Sadahira, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123569/
https://www.ncbi.nlm.nih.gov/pubmed/37093552
http://dx.doi.org/10.1007/s44228-023-00043-9
Descripción
Sumario:Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administration. All patients presented with active hemolysis and high D-dimer levels upon admission. Thromboembolism was confirmed within 2 weeks after starting glucocorticoid, suggesting that both active hemolysis and glucocorticoid administration synergistically contributed to the development of PE/DVT. Clinicians should consider that such synergism may increase the risk of thromboembolism in patients with AIHA, and prophylactic anticoagulation is worth considering in patients after starting glucocorticoid.

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