Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia

Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administrat...

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Autores principales: Shiroshita, Kohei, Okayama, Mikio, Soma, Hiroki, Sato, Yuki, Hayashi, Hiroyoshi, Shiozawa, Yuka, Okamoto, Shinichiro, Sadahira, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123569/
https://www.ncbi.nlm.nih.gov/pubmed/37093552
http://dx.doi.org/10.1007/s44228-023-00043-9
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author Shiroshita, Kohei
Okayama, Mikio
Soma, Hiroki
Sato, Yuki
Hayashi, Hiroyoshi
Shiozawa, Yuka
Okamoto, Shinichiro
Sadahira, Ken
author_facet Shiroshita, Kohei
Okayama, Mikio
Soma, Hiroki
Sato, Yuki
Hayashi, Hiroyoshi
Shiozawa, Yuka
Okamoto, Shinichiro
Sadahira, Ken
author_sort Shiroshita, Kohei
collection PubMed
description Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administration. All patients presented with active hemolysis and high D-dimer levels upon admission. Thromboembolism was confirmed within 2 weeks after starting glucocorticoid, suggesting that both active hemolysis and glucocorticoid administration synergistically contributed to the development of PE/DVT. Clinicians should consider that such synergism may increase the risk of thromboembolism in patients with AIHA, and prophylactic anticoagulation is worth considering in patients after starting glucocorticoid.
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spelling pubmed-101235692023-04-25 Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia Shiroshita, Kohei Okayama, Mikio Soma, Hiroki Sato, Yuki Hayashi, Hiroyoshi Shiozawa, Yuka Okamoto, Shinichiro Sadahira, Ken Clin Hematol Int Correspondence Pulmonary embolism and deep venous thrombosis (PE/DVT) are well-known lethal complications in autoimmune hemolytic anemia (AIHA). However, the impact of their treatment is unclear. Here, we describe three elderly Japanese patients with AIHA who developed PE/DVT early after glucocorticoid administration. All patients presented with active hemolysis and high D-dimer levels upon admission. Thromboembolism was confirmed within 2 weeks after starting glucocorticoid, suggesting that both active hemolysis and glucocorticoid administration synergistically contributed to the development of PE/DVT. Clinicians should consider that such synergism may increase the risk of thromboembolism in patients with AIHA, and prophylactic anticoagulation is worth considering in patients after starting glucocorticoid. Springer Netherlands 2023-04-24 /pmc/articles/PMC10123569/ /pubmed/37093552 http://dx.doi.org/10.1007/s44228-023-00043-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Correspondence
Shiroshita, Kohei
Okayama, Mikio
Soma, Hiroki
Sato, Yuki
Hayashi, Hiroyoshi
Shiozawa, Yuka
Okamoto, Shinichiro
Sadahira, Ken
Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title_full Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title_fullStr Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title_full_unstemmed Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title_short Thromboembolism Early After Glucocorticoid Administration in Patients with Autoimmune Hemolytic Anemia
title_sort thromboembolism early after glucocorticoid administration in patients with autoimmune hemolytic anemia
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123569/
https://www.ncbi.nlm.nih.gov/pubmed/37093552
http://dx.doi.org/10.1007/s44228-023-00043-9
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