SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone

We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of n...

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Detalles Bibliográficos
Autores principales: Razazi, Keyvan, Martins Bexiga, Anissa, Arrestier, Romain, Peiffer, Bastien, Voiriot, Guillaume, Luyt, Charles-Edouard, Urbina, Tomas, Mayaux, Julien, Pham, Tài, Roux, Damien, Bellaiche, Raphael, AIt Hamou, Zakaria, Gaudry, Stéphane, Azoulay, Elie, Mekontso Dessap, Armand, Rodriguez, Christophe, Pawlotsky, Jean-Michel, Fourati, Slim, de Prost, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123590/
https://www.ncbi.nlm.nih.gov/pubmed/37095145
http://dx.doi.org/10.1038/s41598-023-33639-5
Descripción
Sumario:We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.

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