Cargando…
SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone
We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of n...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123590/ https://www.ncbi.nlm.nih.gov/pubmed/37095145 http://dx.doi.org/10.1038/s41598-023-33639-5 |
| _version_ | 1785029687716610048 |
|---|---|
| author | Razazi, Keyvan Martins Bexiga, Anissa Arrestier, Romain Peiffer, Bastien Voiriot, Guillaume Luyt, Charles-Edouard Urbina, Tomas Mayaux, Julien Pham, Tài Roux, Damien Bellaiche, Raphael AIt Hamou, Zakaria Gaudry, Stéphane Azoulay, Elie Mekontso Dessap, Armand Rodriguez, Christophe Pawlotsky, Jean-Michel Fourati, Slim de Prost, Nicolas |
| author_facet | Razazi, Keyvan Martins Bexiga, Anissa Arrestier, Romain Peiffer, Bastien Voiriot, Guillaume Luyt, Charles-Edouard Urbina, Tomas Mayaux, Julien Pham, Tài Roux, Damien Bellaiche, Raphael AIt Hamou, Zakaria Gaudry, Stéphane Azoulay, Elie Mekontso Dessap, Armand Rodriguez, Christophe Pawlotsky, Jean-Michel Fourati, Slim de Prost, Nicolas |
| author_sort | Razazi, Keyvan |
| collection | PubMed |
| description | We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern. |
| format | Online Article Text |
| id | pubmed-10123590 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101235902023-04-25 SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone Razazi, Keyvan Martins Bexiga, Anissa Arrestier, Romain Peiffer, Bastien Voiriot, Guillaume Luyt, Charles-Edouard Urbina, Tomas Mayaux, Julien Pham, Tài Roux, Damien Bellaiche, Raphael AIt Hamou, Zakaria Gaudry, Stéphane Azoulay, Elie Mekontso Dessap, Armand Rodriguez, Christophe Pawlotsky, Jean-Michel Fourati, Slim de Prost, Nicolas Sci Rep Article We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern. Nature Publishing Group UK 2023-04-24 /pmc/articles/PMC10123590/ /pubmed/37095145 http://dx.doi.org/10.1038/s41598-023-33639-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Razazi, Keyvan Martins Bexiga, Anissa Arrestier, Romain Peiffer, Bastien Voiriot, Guillaume Luyt, Charles-Edouard Urbina, Tomas Mayaux, Julien Pham, Tài Roux, Damien Bellaiche, Raphael AIt Hamou, Zakaria Gaudry, Stéphane Azoulay, Elie Mekontso Dessap, Armand Rodriguez, Christophe Pawlotsky, Jean-Michel Fourati, Slim de Prost, Nicolas SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title | SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title_full | SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title_fullStr | SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title_full_unstemmed | SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title_short | SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone |
| title_sort | sars-cov-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill covid-19 patients in the era of dexamethasone |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123590/ https://www.ncbi.nlm.nih.gov/pubmed/37095145 http://dx.doi.org/10.1038/s41598-023-33639-5 |
| work_keys_str_mv | AT razazikeyvan sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT martinsbexigaanissa sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT arrestierromain sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT peifferbastien sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT voiriotguillaume sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT luytcharlesedouard sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT urbinatomas sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT mayauxjulien sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT phamtai sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT rouxdamien sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT bellaicheraphael sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT aithamouzakaria sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT gaudrystephane sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT azoulayelie sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT mekontsodessaparmand sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT rodriguezchristophe sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT pawlotskyjeanmichel sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT fouratislim sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone AT deprostnicolas sarscov2variantsandmutationalpatternsrelationshipwithriskofventilatorassociatedpneumoniaincriticallyillcovid19patientsintheeraofdexamethasone |