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CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multipl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123731/ https://www.ncbi.nlm.nih.gov/pubmed/37092451 http://dx.doi.org/10.3390/antib12020030 |
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author | Gómez-Melero, Sara Caballero-Villarraso, Javier |
author_facet | Gómez-Melero, Sara Caballero-Villarraso, Javier |
author_sort | Gómez-Melero, Sara |
collection | PubMed |
description | The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple sclerosis, HIV infection or rheumatoid arthritis. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local tissues. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 is complicated due to the difficulty in screenings. This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases and the importance of the development of antibodies against CCR6 that could be a promising alternative to small molecules in the treatment of CCR6/CCL20 axis-related pathologies. |
format | Online Article Text |
id | pubmed-10123731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101237312023-04-25 CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases Gómez-Melero, Sara Caballero-Villarraso, Javier Antibodies (Basel) Review The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling network is produced. This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple sclerosis, HIV infection or rheumatoid arthritis. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local tissues. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 is complicated due to the difficulty in screenings. This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases and the importance of the development of antibodies against CCR6 that could be a promising alternative to small molecules in the treatment of CCR6/CCL20 axis-related pathologies. MDPI 2023-04-20 /pmc/articles/PMC10123731/ /pubmed/37092451 http://dx.doi.org/10.3390/antib12020030 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gómez-Melero, Sara Caballero-Villarraso, Javier CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title | CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title_full | CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title_fullStr | CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title_full_unstemmed | CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title_short | CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases |
title_sort | ccr6 as a potential target for therapeutic antibodies for the treatment of inflammatory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123731/ https://www.ncbi.nlm.nih.gov/pubmed/37092451 http://dx.doi.org/10.3390/antib12020030 |
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