Cargando…

An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen,...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Mathew, Wazir, Ali, Karikehalli, Shridevi, Sandhu, Michael, Poudel, Aarati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123893/
https://www.ncbi.nlm.nih.gov/pubmed/37073478
http://dx.doi.org/10.1177/23247096231168105
_version_ 1785029745498390528
author Thomas, Mathew
Wazir, Ali
Karikehalli, Shridevi
Sandhu, Michael
Poudel, Aarati
author_facet Thomas, Mathew
Wazir, Ali
Karikehalli, Shridevi
Sandhu, Michael
Poudel, Aarati
author_sort Thomas, Mathew
collection PubMed
description Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL.
format Online
Article
Text
id pubmed-10123893
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-101238932023-04-25 An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia Thomas, Mathew Wazir, Ali Karikehalli, Shridevi Sandhu, Michael Poudel, Aarati J Investig Med High Impact Case Rep Case Report Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL. SAGE Publications 2023-04-18 /pmc/articles/PMC10123893/ /pubmed/37073478 http://dx.doi.org/10.1177/23247096231168105 Text en © 2023 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Thomas, Mathew
Wazir, Ali
Karikehalli, Shridevi
Sandhu, Michael
Poudel, Aarati
An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title_full An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title_fullStr An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title_full_unstemmed An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title_short An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
title_sort extremely rare case of prostate and bladder wall involvement of chronic lymphocytic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123893/
https://www.ncbi.nlm.nih.gov/pubmed/37073478
http://dx.doi.org/10.1177/23247096231168105
work_keys_str_mv AT thomasmathew anextremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT wazirali anextremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT karikehallishridevi anextremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT sandhumichael anextremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT poudelaarati anextremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT thomasmathew extremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT wazirali extremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT karikehallishridevi extremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT sandhumichael extremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia
AT poudelaarati extremelyrarecaseofprostateandbladderwallinvolvementofchroniclymphocyticleukemia