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An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123893/ https://www.ncbi.nlm.nih.gov/pubmed/37073478 http://dx.doi.org/10.1177/23247096231168105 |
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author | Thomas, Mathew Wazir, Ali Karikehalli, Shridevi Sandhu, Michael Poudel, Aarati |
author_facet | Thomas, Mathew Wazir, Ali Karikehalli, Shridevi Sandhu, Michael Poudel, Aarati |
author_sort | Thomas, Mathew |
collection | PubMed |
description | Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL. |
format | Online Article Text |
id | pubmed-10123893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-101238932023-04-25 An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia Thomas, Mathew Wazir, Ali Karikehalli, Shridevi Sandhu, Michael Poudel, Aarati J Investig Med High Impact Case Rep Case Report Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and is characterized by monoclonal proliferation of B-cell lymphocytes which are morphologically mature, but immunologically dysfunctional. The primary sites of disease involvement include peripheral blood, lymph nodes, spleen, and bone marrow. CLL can also present locally and aggressively at extranodal sites. We describe the case of a 74-year-old gentleman with multiple medical comorbidities who was Foley catheter–dependent at baseline for bladder outlet obstruction. He was detected to have Rai stage I CLL following an inguinal lymph node biopsy and was on regular outpatient surveillance. Later, he underwent a prostate biopsy for evaluation of hematuria, results of which were consistent with CLL involvement in the prostate and urinary bladder. The patient was started on single-agent ibrutinib, and demonstrated an excellent clinical response to bladder outlet obstruction. His long-term Foley catheter was discontinued within 5 days of ibrutinib therapy. Unfortunately, 1 year later, he had disease progression, and therapy was changed to a single-agent rituximab, to which he is responding well. Our case is unique as it brings up the first reported case of prostate and bladder wall CLL. SAGE Publications 2023-04-18 /pmc/articles/PMC10123893/ /pubmed/37073478 http://dx.doi.org/10.1177/23247096231168105 Text en © 2023 American Federation for Medical Research https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Thomas, Mathew Wazir, Ali Karikehalli, Shridevi Sandhu, Michael Poudel, Aarati An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title_full | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title_fullStr | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title_full_unstemmed | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title_short | An Extremely Rare Case of Prostate and Bladder Wall Involvement of Chronic Lymphocytic Leukemia |
title_sort | extremely rare case of prostate and bladder wall involvement of chronic lymphocytic leukemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123893/ https://www.ncbi.nlm.nih.gov/pubmed/37073478 http://dx.doi.org/10.1177/23247096231168105 |
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