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Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors

Deep vein thrombosis (DVT) and the associated possible complication of pulmonary artery embolism (LAE) represent a recognized reason for significant perioperative morbidity and mortality. There is a risk of pulmonary artery embolism through embolization. The aim of the study was to investigate the i...

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Autores principales: Simon, Miriam Anna, Klaeffling, Christina, Ward, Josephine, Rauchfuss, Steffen, Miesbach, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123917/
https://www.ncbi.nlm.nih.gov/pubmed/37069796
http://dx.doi.org/10.1177/10760296231152898
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author Simon, Miriam Anna
Klaeffling, Christina
Ward, Josephine
Rauchfuss, Steffen
Miesbach, Wolfgang
author_facet Simon, Miriam Anna
Klaeffling, Christina
Ward, Josephine
Rauchfuss, Steffen
Miesbach, Wolfgang
author_sort Simon, Miriam Anna
collection PubMed
description Deep vein thrombosis (DVT) and the associated possible complication of pulmonary artery embolism (LAE) represent a recognized reason for significant perioperative morbidity and mortality. There is a risk of pulmonary artery embolism through embolization. The aim of the study was to investigate the influence of various risk factors on the clinical outcome of the therapy, particularly regarding whether maintenance therapy offers a benefit in terms of the frequency of bleeding and thrombotic events. 80 patients were included, some of them retrospectively from July 2018. The observational period was set to 12 months after the DVT event. In the present sample with n = 80, with 57.5% men and 42.5% women (after 12 months of observation: n = 78), a success rate of the therapies administered of 89.7% was recorded. Only 8.9% showed partial recanalization. 3.8% of the patients had a relapse (also beyond the localization of the leg and pelvic veins) and 8.8% had a residual thrombus during the first 12 months of observation. In this study, BARC (Bleeding Academic Research Consortium) and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) scores for identifying the risk of bleeding and Wells scores for assessing the risk of having a thrombosis were used. The Villalta score tested in this study showed significant correlations with residual thrombus (P < .001), recurrence within 12 months (P < .001), and the risk of bleeding (P < .001) and is capable to provide an assessment of the variables mentioned not only at the possible end of therapy but also at the start of anticoagulant therapy.
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spelling pubmed-101239172023-04-25 Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors Simon, Miriam Anna Klaeffling, Christina Ward, Josephine Rauchfuss, Steffen Miesbach, Wolfgang Clin Appl Thromb Hemost Original Manuscript Deep vein thrombosis (DVT) and the associated possible complication of pulmonary artery embolism (LAE) represent a recognized reason for significant perioperative morbidity and mortality. There is a risk of pulmonary artery embolism through embolization. The aim of the study was to investigate the influence of various risk factors on the clinical outcome of the therapy, particularly regarding whether maintenance therapy offers a benefit in terms of the frequency of bleeding and thrombotic events. 80 patients were included, some of them retrospectively from July 2018. The observational period was set to 12 months after the DVT event. In the present sample with n = 80, with 57.5% men and 42.5% women (after 12 months of observation: n = 78), a success rate of the therapies administered of 89.7% was recorded. Only 8.9% showed partial recanalization. 3.8% of the patients had a relapse (also beyond the localization of the leg and pelvic veins) and 8.8% had a residual thrombus during the first 12 months of observation. In this study, BARC (Bleeding Academic Research Consortium) and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) scores for identifying the risk of bleeding and Wells scores for assessing the risk of having a thrombosis were used. The Villalta score tested in this study showed significant correlations with residual thrombus (P < .001), recurrence within 12 months (P < .001), and the risk of bleeding (P < .001) and is capable to provide an assessment of the variables mentioned not only at the possible end of therapy but also at the start of anticoagulant therapy. SAGE Publications 2023-04-17 /pmc/articles/PMC10123917/ /pubmed/37069796 http://dx.doi.org/10.1177/10760296231152898 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Simon, Miriam Anna
Klaeffling, Christina
Ward, Josephine
Rauchfuss, Steffen
Miesbach, Wolfgang
Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title_full Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title_fullStr Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title_full_unstemmed Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title_short Clinical Outcome of Deep Vein Thrombosis Is Related to Thrombophilic Risk Factors
title_sort clinical outcome of deep vein thrombosis is related to thrombophilic risk factors
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123917/
https://www.ncbi.nlm.nih.gov/pubmed/37069796
http://dx.doi.org/10.1177/10760296231152898
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