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Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes

BACKGROUND: Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. METHODS: Data of 1,376,540 participants aged...

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Autores principales: Lee, Min-Kyung, Lee, Jae-Hyuk, Sohn, Seo Young, Ahn, Jiyeon, Hong, Oak-Kee, Kim, Mee-Kyoung, Baek, Ki-Hyun, Song, Ki-Ho, Han, Kyungdo, Kwon, Hyuk-Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123975/
https://www.ncbi.nlm.nih.gov/pubmed/37095558
http://dx.doi.org/10.1186/s13098-023-01030-z
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author Lee, Min-Kyung
Lee, Jae-Hyuk
Sohn, Seo Young
Ahn, Jiyeon
Hong, Oak-Kee
Kim, Mee-Kyoung
Baek, Ki-Hyun
Song, Ki-Ho
Han, Kyungdo
Kwon, Hyuk-Sang
author_facet Lee, Min-Kyung
Lee, Jae-Hyuk
Sohn, Seo Young
Ahn, Jiyeon
Hong, Oak-Kee
Kim, Mee-Kyoung
Baek, Ki-Hyun
Song, Ki-Ho
Han, Kyungdo
Kwon, Hyuk-Sang
author_sort Lee, Min-Kyung
collection PubMed
description BACKGROUND: Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. METHODS: Data of 1,376,540 participants aged 20–39 years without a history of type 2 diabetes and who underwent four annual health check-ups were collected. In this large-scale prospective cohort study, we evaluated the incidence rates and hazard ratios (HRs) of diabetes according to cumulative frequencies of metabolic syndrome over 4 years of consecutive annual health check-ups (burden score 0–4). Subgroup analyses were performed by sex and age. RESULTS: During 5.18 years of follow-up, 18,155 young adults developed type 2 diabetes. The incidence of type 2 diabetes increased with burden score (P < 0.0001). The multivariable-adjusted HRs for type 2 diabetes were 4.757, 10.511, 18.288, and 31.749 in participants with a burden score of 1 to 4, respectively, compared to those with 0. In subgroup analyses, the risk of incident diabetes was greater in women than men and in the 20–29 years age group than the 30–39 years age group. The HRs were 47.473 in women and 27.852 in men with four burden scores. CONCLUSION: The risk of type 2 diabetes significantly increased with an increase in the cumulative burden of metabolic syndrome in young adults. Additionally, the association between cumulative burden and diabetes risk was stronger in women and the 20s age group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13098-023-01030-z.
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spelling pubmed-101239752023-04-25 Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes Lee, Min-Kyung Lee, Jae-Hyuk Sohn, Seo Young Ahn, Jiyeon Hong, Oak-Kee Kim, Mee-Kyoung Baek, Ki-Hyun Song, Ki-Ho Han, Kyungdo Kwon, Hyuk-Sang Diabetol Metab Syndr Research BACKGROUND: Metabolic syndrome is associated with type 2 diabetes and its prevalence is increasing worldwide in young adults. We aimed to determine whether cumulative exposure to metabolic syndrome is associated with type 2 diabetes risk in young adults. METHODS: Data of 1,376,540 participants aged 20–39 years without a history of type 2 diabetes and who underwent four annual health check-ups were collected. In this large-scale prospective cohort study, we evaluated the incidence rates and hazard ratios (HRs) of diabetes according to cumulative frequencies of metabolic syndrome over 4 years of consecutive annual health check-ups (burden score 0–4). Subgroup analyses were performed by sex and age. RESULTS: During 5.18 years of follow-up, 18,155 young adults developed type 2 diabetes. The incidence of type 2 diabetes increased with burden score (P < 0.0001). The multivariable-adjusted HRs for type 2 diabetes were 4.757, 10.511, 18.288, and 31.749 in participants with a burden score of 1 to 4, respectively, compared to those with 0. In subgroup analyses, the risk of incident diabetes was greater in women than men and in the 20–29 years age group than the 30–39 years age group. The HRs were 47.473 in women and 27.852 in men with four burden scores. CONCLUSION: The risk of type 2 diabetes significantly increased with an increase in the cumulative burden of metabolic syndrome in young adults. Additionally, the association between cumulative burden and diabetes risk was stronger in women and the 20s age group. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13098-023-01030-z. BioMed Central 2023-04-24 /pmc/articles/PMC10123975/ /pubmed/37095558 http://dx.doi.org/10.1186/s13098-023-01030-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lee, Min-Kyung
Lee, Jae-Hyuk
Sohn, Seo Young
Ahn, Jiyeon
Hong, Oak-Kee
Kim, Mee-Kyoung
Baek, Ki-Hyun
Song, Ki-Ho
Han, Kyungdo
Kwon, Hyuk-Sang
Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title_full Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title_fullStr Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title_full_unstemmed Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title_short Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
title_sort cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123975/
https://www.ncbi.nlm.nih.gov/pubmed/37095558
http://dx.doi.org/10.1186/s13098-023-01030-z
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