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Meta-analysis of Osteopontin splice variants in cancer

BACKGROUND: The cytokine Osteopontin is a mediator of tumor progression and cancer metastasis. In 2006, we reported that (in addition to the full-length form -a) splice variants of Osteopontin (forms -b and -c) are produced selectively by transformed cells. Through June 2021, 36 PubMed-indexed journ...

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Autores principales: An, Yu, Fnu, Gulimirerouzi, Xie, Changchun, Weber, Georg F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124019/
https://www.ncbi.nlm.nih.gov/pubmed/37095438
http://dx.doi.org/10.1186/s12885-023-10854-x
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author An, Yu
Fnu, Gulimirerouzi
Xie, Changchun
Weber, Georg F.
author_facet An, Yu
Fnu, Gulimirerouzi
Xie, Changchun
Weber, Georg F.
author_sort An, Yu
collection PubMed
description BACKGROUND: The cytokine Osteopontin is a mediator of tumor progression and cancer metastasis. In 2006, we reported that (in addition to the full-length form -a) splice variants of Osteopontin (forms -b and -c) are produced selectively by transformed cells. Through June 2021, 36 PubMed-indexed journal articles have studied Osteopontin splice variants in various cancer patients. METHODS: Applying a categorical approach previously developed by us, here we conduct a meta-analysis of the pertinent literature. We supplement this with evaluation of the relevant entries in the TSVdb database, which focusses on splice variant expression, thus including the additional variants -4 and -5. The analysis covers 5886 patients across 15 tumors from the literature and 10,446 patients across 33 tumors from TSVdb. RESULTS: The database yields positive results more frequently than the categorical meta-analysis. The two sources are in agreement on the elevation of OPN-a, OPN-b, and OPN-c in lung cancer and the elevation of OPN-c in breast cancer as compared to healthy tissue. Specific splice variants are associated with grade, stage, or patient survival pertaining to various cancers. CONCLUSIONS: There are cases of persisting discrepancies, which require further investigation to clarify the Osteopontin splice variant utilization, so that their diagnostic, prognostic and potentially predictive potential can be brought to fruition. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10854-x.
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spelling pubmed-101240192023-04-25 Meta-analysis of Osteopontin splice variants in cancer An, Yu Fnu, Gulimirerouzi Xie, Changchun Weber, Georg F. BMC Cancer Research Article BACKGROUND: The cytokine Osteopontin is a mediator of tumor progression and cancer metastasis. In 2006, we reported that (in addition to the full-length form -a) splice variants of Osteopontin (forms -b and -c) are produced selectively by transformed cells. Through June 2021, 36 PubMed-indexed journal articles have studied Osteopontin splice variants in various cancer patients. METHODS: Applying a categorical approach previously developed by us, here we conduct a meta-analysis of the pertinent literature. We supplement this with evaluation of the relevant entries in the TSVdb database, which focusses on splice variant expression, thus including the additional variants -4 and -5. The analysis covers 5886 patients across 15 tumors from the literature and 10,446 patients across 33 tumors from TSVdb. RESULTS: The database yields positive results more frequently than the categorical meta-analysis. The two sources are in agreement on the elevation of OPN-a, OPN-b, and OPN-c in lung cancer and the elevation of OPN-c in breast cancer as compared to healthy tissue. Specific splice variants are associated with grade, stage, or patient survival pertaining to various cancers. CONCLUSIONS: There are cases of persisting discrepancies, which require further investigation to clarify the Osteopontin splice variant utilization, so that their diagnostic, prognostic and potentially predictive potential can be brought to fruition. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-10854-x. BioMed Central 2023-04-24 /pmc/articles/PMC10124019/ /pubmed/37095438 http://dx.doi.org/10.1186/s12885-023-10854-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
An, Yu
Fnu, Gulimirerouzi
Xie, Changchun
Weber, Georg F.
Meta-analysis of Osteopontin splice variants in cancer
title Meta-analysis of Osteopontin splice variants in cancer
title_full Meta-analysis of Osteopontin splice variants in cancer
title_fullStr Meta-analysis of Osteopontin splice variants in cancer
title_full_unstemmed Meta-analysis of Osteopontin splice variants in cancer
title_short Meta-analysis of Osteopontin splice variants in cancer
title_sort meta-analysis of osteopontin splice variants in cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124019/
https://www.ncbi.nlm.nih.gov/pubmed/37095438
http://dx.doi.org/10.1186/s12885-023-10854-x
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