A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit

BACKGROUND: DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, and they can cause cancer if improperly repaired. Recent chromosome conformation capture techniques, such as Hi-C, have enabled the identification of relationships between the 3D chromatin structure and DSBs, but...

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Detalles Bibliográficos
Autores principales: Sun, Yu, Xu, Xiang, Lin, Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Tao, Huan, Wang, Xu, Zhao, Huan, Tu, Weiwei, Bai, Xuemei, Wang, Junting, Huang, Qiya, Li, Yaru, Chen, Hebing, Li, Hao, Bo, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124043/
https://www.ncbi.nlm.nih.gov/pubmed/37095580
http://dx.doi.org/10.1186/s13059-023-02916-x

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