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Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study
OBJECTIVES: To assess the associations of lactate level or lactate clearance at different time points with in-hospital mortality in critically ill patients with acute myocardial infarction (AMI). DESIGN: A cohort study. SETTING: The Medical Information Mart for Intensive Care III database. PARTICIPA...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124257/ https://www.ncbi.nlm.nih.gov/pubmed/37085300 http://dx.doi.org/10.1136/bmjopen-2022-069129 |
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author | Li, Hongwu Chen, Jingyi Xing, Xinyue Lou, Danfei |
author_facet | Li, Hongwu Chen, Jingyi Xing, Xinyue Lou, Danfei |
author_sort | Li, Hongwu |
collection | PubMed |
description | OBJECTIVES: To assess the associations of lactate level or lactate clearance at different time points with in-hospital mortality in critically ill patients with acute myocardial infarction (AMI). DESIGN: A cohort study. SETTING: The Medical Information Mart for Intensive Care III database. PARTICIPANT: 490 AMI patients. INTERVENTION: None. PRIMARY AND SECONDARY OUTCOME MEASURES: In-hospital mortality of patients. RESULTS: In total, 120 (24.49%) patients died at the end of follow-up. After adjusting for confounders, increased risk of in-hospital mortality in patients with AMI was observed in those with high lactate level (24 hours) (HR=1.156, 95%CI: 1.002 to 1.333). Increased lactate clearance (24 hours) was correlated with a decreased risk of in-hospital mortality in patients with AMI (HR=0.995, 95% CI: 0.994 to 0.997). The area under the curves (AUCs) of lactate level (24 hours) and lactate clearance (24 hours) were 0.689 (95% CI: 0.655 to 0.723) and 0.672 (95% CI: 0.637 to 0.706), respectively. The AUC of lactate level (24 hours) and lactate clearance (24 hours) was higher than lactate level (baseline). CONCLUSIONS: Increased lactate level (24 hours) was associated with an elevated risk of in-hospital mortality in patients with AMI and increased lactate clearance (24 hours) was correlated with a decreased risk of in-hospital mortality in patients with AMI despite the age and genders. |
format | Online Article Text |
id | pubmed-10124257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-101242572023-04-25 Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study Li, Hongwu Chen, Jingyi Xing, Xinyue Lou, Danfei BMJ Open Cardiovascular Medicine OBJECTIVES: To assess the associations of lactate level or lactate clearance at different time points with in-hospital mortality in critically ill patients with acute myocardial infarction (AMI). DESIGN: A cohort study. SETTING: The Medical Information Mart for Intensive Care III database. PARTICIPANT: 490 AMI patients. INTERVENTION: None. PRIMARY AND SECONDARY OUTCOME MEASURES: In-hospital mortality of patients. RESULTS: In total, 120 (24.49%) patients died at the end of follow-up. After adjusting for confounders, increased risk of in-hospital mortality in patients with AMI was observed in those with high lactate level (24 hours) (HR=1.156, 95%CI: 1.002 to 1.333). Increased lactate clearance (24 hours) was correlated with a decreased risk of in-hospital mortality in patients with AMI (HR=0.995, 95% CI: 0.994 to 0.997). The area under the curves (AUCs) of lactate level (24 hours) and lactate clearance (24 hours) were 0.689 (95% CI: 0.655 to 0.723) and 0.672 (95% CI: 0.637 to 0.706), respectively. The AUC of lactate level (24 hours) and lactate clearance (24 hours) was higher than lactate level (baseline). CONCLUSIONS: Increased lactate level (24 hours) was associated with an elevated risk of in-hospital mortality in patients with AMI and increased lactate clearance (24 hours) was correlated with a decreased risk of in-hospital mortality in patients with AMI despite the age and genders. BMJ Publishing Group 2023-04-21 /pmc/articles/PMC10124257/ /pubmed/37085300 http://dx.doi.org/10.1136/bmjopen-2022-069129 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Cardiovascular Medicine Li, Hongwu Chen, Jingyi Xing, Xinyue Lou, Danfei Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title | Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title_full | Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title_fullStr | Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title_full_unstemmed | Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title_short | Association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
title_sort | association of lactate detection with in-hospital mortality in critically ill patients with acute myocardial infarction: a retrospective cohort study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124257/ https://www.ncbi.nlm.nih.gov/pubmed/37085300 http://dx.doi.org/10.1136/bmjopen-2022-069129 |
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