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Ectopic expression of cGAS in Salmonella typhimurium enhances STING-mediated IFN-β response in human macrophages and dendritic cells

BACKGROUND: Interferon (IFN)-β induction via activation of the stimulator of interferon genes (STING) pathway has shown promising results in tumor models. STING is activated by cyclic dinucleotides such as cyclic GMP–AMP dinucleotides with phosphodiester linkages 2′–5′ and 3′–5′ (cGAMPs), that are p...

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Detalles Bibliográficos
Autores principales:	Waanders, Lisette, van der Donk, Lieve E H, Ates, Louis S, Maaskant, Janneke, van Hamme, John L, Eldering, Eric, van Bruggen, Jaco A C, Rietveld, Joanne M, Bitter, Wilbert, Geijtenbeek, Teunis B H, Kuijl, Coenraad P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124277/ https://www.ncbi.nlm.nih.gov/pubmed/37072345 http://dx.doi.org/10.1136/jitc-2022-005839

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