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Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications
PURPOSE: Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioper...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124280/ https://www.ncbi.nlm.nih.gov/pubmed/37076142 http://dx.doi.org/10.1136/bmjopen-2022-068970 |
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author | de Mul, Nikki Verlaan, Diede Ruurda, Jelle P van Grevenstein, Wilhelmina M U Hagendoorn, Jeroen de Borst, Gert-Jan Vriens, Menno R de Bree, Remco Zweemer, Ronald P Vogely, Charles Haitsma Mulier, Jelle L G Vernooij, Lisette M Reitsma, Johannes B de Zoete, Marcel R Top, Janetta Kluijtmans, Jan A J Hoefer, Imo E Noordzij, Peter Rettig, Thijs Marsman, Marije de Smet, Anne Marie G A Derde, Lennie van Waes, Judith Rijsdijk, Mienke Schellekens, Willem Jan M Bonten, Marc J M Slooter, Arjen J C Cremer, Olaf L |
author_facet | de Mul, Nikki Verlaan, Diede Ruurda, Jelle P van Grevenstein, Wilhelmina M U Hagendoorn, Jeroen de Borst, Gert-Jan Vriens, Menno R de Bree, Remco Zweemer, Ronald P Vogely, Charles Haitsma Mulier, Jelle L G Vernooij, Lisette M Reitsma, Johannes B de Zoete, Marcel R Top, Janetta Kluijtmans, Jan A J Hoefer, Imo E Noordzij, Peter Rettig, Thijs Marsman, Marije de Smet, Anne Marie G A Derde, Lennie van Waes, Judith Rijsdijk, Mienke Schellekens, Willem Jan M Bonten, Marc J M Slooter, Arjen J C Cremer, Olaf L |
author_sort | de Mul, Nikki |
collection | PubMed |
description | PURPOSE: Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioperative longitudinal study of complications and long-term outcomes (PLUTO) cohort aims to establish a comprehensive biorepository that will facilitate research in this field. In this profile paper, we will discuss its design rationale and opportunities for future studies. PARTICIPANTS: Patients undergoing elective intermediate to high-risk non-cardiac surgery are eligible for enrolment. For the first seven postoperative days, participants are subjected to daily bedside visits by dedicated observers, who adjudicate clinical events and perform non-invasive physiological measurements (including handheld spirometry and single-channel electroencephalography). Blood samples and microbiome specimens are collected at preselected time points. Primary study outcomes are the postoperative occurrence of nosocomial infections, major adverse cardiac events, pulmonary complications, acute kidney injury and delirium/acute encephalopathy. Secondary outcomes include mortality and quality of life, as well as the long-term occurrence of psychopathology, cognitive dysfunction and chronic pain. FINDINGS TO DATE: Enrolment of the first participant occurred early 2020. During the inception phase of the project (first 2 years), 431 patients were eligible of whom 297 patients consented to participate (69%). Observed event rate was 42% overall, with the most frequent complication being infection. FUTURE PLANS: The main purpose of the PLUTO biorepository is to provide a framework for research in the field of perioperative medicine and anaesthesiology, by storing high-quality clinical data and biomaterials for future studies. In addition, PLUTO aims to establish a logistical platform for conducting embedded clinical trials. TRIAL REGISTRATION NUMBER: NCT05331118. |
format | Online Article Text |
id | pubmed-10124280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-101242802023-04-25 Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications de Mul, Nikki Verlaan, Diede Ruurda, Jelle P van Grevenstein, Wilhelmina M U Hagendoorn, Jeroen de Borst, Gert-Jan Vriens, Menno R de Bree, Remco Zweemer, Ronald P Vogely, Charles Haitsma Mulier, Jelle L G Vernooij, Lisette M Reitsma, Johannes B de Zoete, Marcel R Top, Janetta Kluijtmans, Jan A J Hoefer, Imo E Noordzij, Peter Rettig, Thijs Marsman, Marije de Smet, Anne Marie G A Derde, Lennie van Waes, Judith Rijsdijk, Mienke Schellekens, Willem Jan M Bonten, Marc J M Slooter, Arjen J C Cremer, Olaf L BMJ Open Anaesthesia PURPOSE: Although elective surgery is generally safe, some procedures remain associated with an increased risk of complications. Improved preoperative risk stratification and earlier recognition of these complications may ameliorate postoperative recovery and improve long-term outcomes. The perioperative longitudinal study of complications and long-term outcomes (PLUTO) cohort aims to establish a comprehensive biorepository that will facilitate research in this field. In this profile paper, we will discuss its design rationale and opportunities for future studies. PARTICIPANTS: Patients undergoing elective intermediate to high-risk non-cardiac surgery are eligible for enrolment. For the first seven postoperative days, participants are subjected to daily bedside visits by dedicated observers, who adjudicate clinical events and perform non-invasive physiological measurements (including handheld spirometry and single-channel electroencephalography). Blood samples and microbiome specimens are collected at preselected time points. Primary study outcomes are the postoperative occurrence of nosocomial infections, major adverse cardiac events, pulmonary complications, acute kidney injury and delirium/acute encephalopathy. Secondary outcomes include mortality and quality of life, as well as the long-term occurrence of psychopathology, cognitive dysfunction and chronic pain. FINDINGS TO DATE: Enrolment of the first participant occurred early 2020. During the inception phase of the project (first 2 years), 431 patients were eligible of whom 297 patients consented to participate (69%). Observed event rate was 42% overall, with the most frequent complication being infection. FUTURE PLANS: The main purpose of the PLUTO biorepository is to provide a framework for research in the field of perioperative medicine and anaesthesiology, by storing high-quality clinical data and biomaterials for future studies. In addition, PLUTO aims to establish a logistical platform for conducting embedded clinical trials. TRIAL REGISTRATION NUMBER: NCT05331118. BMJ Publishing Group 2023-04-19 /pmc/articles/PMC10124280/ /pubmed/37076142 http://dx.doi.org/10.1136/bmjopen-2022-068970 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Anaesthesia de Mul, Nikki Verlaan, Diede Ruurda, Jelle P van Grevenstein, Wilhelmina M U Hagendoorn, Jeroen de Borst, Gert-Jan Vriens, Menno R de Bree, Remco Zweemer, Ronald P Vogely, Charles Haitsma Mulier, Jelle L G Vernooij, Lisette M Reitsma, Johannes B de Zoete, Marcel R Top, Janetta Kluijtmans, Jan A J Hoefer, Imo E Noordzij, Peter Rettig, Thijs Marsman, Marije de Smet, Anne Marie G A Derde, Lennie van Waes, Judith Rijsdijk, Mienke Schellekens, Willem Jan M Bonten, Marc J M Slooter, Arjen J C Cremer, Olaf L Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title_full | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title_fullStr | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title_full_unstemmed | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title_short | Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
title_sort | cohort profile of pluto: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications |
topic | Anaesthesia |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124280/ https://www.ncbi.nlm.nih.gov/pubmed/37076142 http://dx.doi.org/10.1136/bmjopen-2022-068970 |
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