Intratumor childhood vaccine-specific CD4(+) T-cell recall coordinates antitumor CD8(+) T cells and eosinophils

BACKGROUND: Antitumor mechanisms of CD4(+) T cells remain crudely defined, and means to effectively harness CD4(+) T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4(+) T cells hold potential to be leveraged for this purpose. Moreover, the role of pre-existing immunity in viro...

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Detalles Bibliográficos
Autores principales: Brown, Michael C, Beasley, Georgia M, McKay, Zachary P, Yang, Yuanfan, Desjardins, Annick, Randazzo, Dina M, Landi, Daniel, Ashley, David M, Bigner, Darell D, Nair, Smita K, Gromeier, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124325/
https://www.ncbi.nlm.nih.gov/pubmed/37072349
http://dx.doi.org/10.1136/jitc-2022-006463

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