Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions

Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantit...

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Detalles Bibliográficos
Autores principales: de le Roi, Madeleine, Puff, Christina, Wohlsein, Peter, Pfaff, Florian, Beer, Martin, Baumgärtner, Wolfgang, Rubbenstroth, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124629/
https://www.ncbi.nlm.nih.gov/pubmed/37081716
http://dx.doi.org/10.3201/eid2905.230172
Descripción
Sumario:Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization.

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