Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB

New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-ol...

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Autores principales: Millard, James, Rimmer, Stephanie, Nimmo, Camus, O’Donnell, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124645/
https://www.ncbi.nlm.nih.gov/pubmed/37081529
http://dx.doi.org/10.3201/eid2905.221716
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author Millard, James
Rimmer, Stephanie
Nimmo, Camus
O’Donnell, Max
author_facet Millard, James
Rimmer, Stephanie
Nimmo, Camus
O’Donnell, Max
author_sort Millard, James
collection PubMed
description New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-old woman in South Africa with extensively drug-resistant tuberculosis and known HIV.
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spelling pubmed-101246452023-05-01 Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB Millard, James Rimmer, Stephanie Nimmo, Camus O’Donnell, Max Emerg Infect Dis Research Letter New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance. We report a case of bedaquiline and delamanid resistance in a 55-year-old woman in South Africa with extensively drug-resistant tuberculosis and known HIV. Centers for Disease Control and Prevention 2023-05 /pmc/articles/PMC10124645/ /pubmed/37081529 http://dx.doi.org/10.3201/eid2905.221716 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Millard, James
Rimmer, Stephanie
Nimmo, Camus
O’Donnell, Max
Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title_full Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title_fullStr Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title_full_unstemmed Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title_short Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB
title_sort therapeutic failure and acquired bedaquiline and delamanid resistance in treatment of drug-resistant tb
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124645/
https://www.ncbi.nlm.nih.gov/pubmed/37081529
http://dx.doi.org/10.3201/eid2905.221716
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