Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics

We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis–related strains as parents. Our findings highlight the existence of poorly sampled Leishma...

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Autores principales: Van den Broeck, Frederik, Heeren, Senne, Maes, Ilse, Sanders, Mandy, Cotton, James A., Cupolillo, Elisa, Alvarez, Eugenia, Garcia, Lineth, Tasia, Maureen, Marneffe, Alice, Dujardin, Jean-Claude, Van der Auwera, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124652/
https://www.ncbi.nlm.nih.gov/pubmed/37081624
http://dx.doi.org/10.3201/eid2905.221456
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author Van den Broeck, Frederik
Heeren, Senne
Maes, Ilse
Sanders, Mandy
Cotton, James A.
Cupolillo, Elisa
Alvarez, Eugenia
Garcia, Lineth
Tasia, Maureen
Marneffe, Alice
Dujardin, Jean-Claude
Van der Auwera, Gert
author_facet Van den Broeck, Frederik
Heeren, Senne
Maes, Ilse
Sanders, Mandy
Cotton, James A.
Cupolillo, Elisa
Alvarez, Eugenia
Garcia, Lineth
Tasia, Maureen
Marneffe, Alice
Dujardin, Jean-Claude
Van der Auwera, Gert
author_sort Van den Broeck, Frederik
collection PubMed
description We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis–related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans.
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spelling pubmed-101246522023-05-01 Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics Van den Broeck, Frederik Heeren, Senne Maes, Ilse Sanders, Mandy Cotton, James A. Cupolillo, Elisa Alvarez, Eugenia Garcia, Lineth Tasia, Maureen Marneffe, Alice Dujardin, Jean-Claude Van der Auwera, Gert Emerg Infect Dis Research Letter We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis–related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans. Centers for Disease Control and Prevention 2023-05 /pmc/articles/PMC10124652/ /pubmed/37081624 http://dx.doi.org/10.3201/eid2905.221456 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Van den Broeck, Frederik
Heeren, Senne
Maes, Ilse
Sanders, Mandy
Cotton, James A.
Cupolillo, Elisa
Alvarez, Eugenia
Garcia, Lineth
Tasia, Maureen
Marneffe, Alice
Dujardin, Jean-Claude
Van der Auwera, Gert
Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title_full Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title_fullStr Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title_full_unstemmed Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title_short Genome Analysis of Triploid Hybrid Leishmania Parasite from the Neotropics
title_sort genome analysis of triploid hybrid leishmania parasite from the neotropics
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124652/
https://www.ncbi.nlm.nih.gov/pubmed/37081624
http://dx.doi.org/10.3201/eid2905.221456
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