Clonorchis sinensis granulin promotes malignant transformation of human intrahepatic biliary epithelial cells through interaction with M2 macrophages via regulation of STAT3  phosphorylation and the MEK/ERK pathway

BACKGROUND: Clonorchis sinensis granulin (CsGRN), a component of the excretory/secretory products of this species, is a multifunctional growth factor that can promote the metastasis of cholangiocarcinoma cells. However, the effect of CsGRN on human intrahepatic biliary epithelial cells (HIBECs) is u...

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Detalles Bibliográficos
Autores principales: He, Qing, Pan, Xiaowen, Yin, Yingxuan, Xu, Anyuan, Yi, Xueqing, Wu, Yinjuan, Li, Xuerong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124682/
https://www.ncbi.nlm.nih.gov/pubmed/37095578
http://dx.doi.org/10.1186/s13071-023-05765-6

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