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Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study

Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and identifies only symptomatic contacts who are PCR positive at the time of sampling. We used serology to detect the relative transmissibility of...

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Autores principales: Gaskell, Katherine M., El Kheir, Natalie, Mirfendesky, Mariyam, Rampling, Tommy, Marks, Michael, Houlihan, Catherine F., Lemonge, Norbert, Bristowe, Hannah, Aslam, Suhail, Kyprianou, Demetra, Nastouli, Eleni, Goldblatt, David, Fielding, Katherine, Moore, David A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124829/
https://www.ncbi.nlm.nih.gov/pubmed/37093796
http://dx.doi.org/10.1371/journal.pone.0284372
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author Gaskell, Katherine M.
El Kheir, Natalie
Mirfendesky, Mariyam
Rampling, Tommy
Marks, Michael
Houlihan, Catherine F.
Lemonge, Norbert
Bristowe, Hannah
Aslam, Suhail
Kyprianou, Demetra
Nastouli, Eleni
Goldblatt, David
Fielding, Katherine
Moore, David A. J.
author_facet Gaskell, Katherine M.
El Kheir, Natalie
Mirfendesky, Mariyam
Rampling, Tommy
Marks, Michael
Houlihan, Catherine F.
Lemonge, Norbert
Bristowe, Hannah
Aslam, Suhail
Kyprianou, Demetra
Nastouli, Eleni
Goldblatt, David
Fielding, Katherine
Moore, David A. J.
author_sort Gaskell, Katherine M.
collection PubMed
description Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and identifies only symptomatic contacts who are PCR positive at the time of sampling. We used serology to detect the relative transmissibility of Alpha Variant of Concern (VOC) to non-VOC SARS-CoV-2 to calculate household secondary attack rates. We identified index patients diagnosed with Alpha and non-VOC SARS-CoV-2 across two London Hospitals between November 2020 and January 2021 during a prolonged and well adhered national lockdown. We completed a household seroprevalence survey and found that 61.8% of non-VOC exposed household contacts were seropositive compared to 82.1% of Alpha exposed household contacts. The odds of infection doubled with exposure to an index diagnosed with Alpha. There was evidence of transmission events in almost all households. Our data strongly support that estimates of SAR should include serological data to improve accuracy and understanding.
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spelling pubmed-101248292023-04-25 Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study Gaskell, Katherine M. El Kheir, Natalie Mirfendesky, Mariyam Rampling, Tommy Marks, Michael Houlihan, Catherine F. Lemonge, Norbert Bristowe, Hannah Aslam, Suhail Kyprianou, Demetra Nastouli, Eleni Goldblatt, David Fielding, Katherine Moore, David A. J. PLoS One Research Article Historically SARS-CoV-2 secondary attack rates (SAR) have been based on PCR positivity on screening symptomatic contacts; this misses transmission events and identifies only symptomatic contacts who are PCR positive at the time of sampling. We used serology to detect the relative transmissibility of Alpha Variant of Concern (VOC) to non-VOC SARS-CoV-2 to calculate household secondary attack rates. We identified index patients diagnosed with Alpha and non-VOC SARS-CoV-2 across two London Hospitals between November 2020 and January 2021 during a prolonged and well adhered national lockdown. We completed a household seroprevalence survey and found that 61.8% of non-VOC exposed household contacts were seropositive compared to 82.1% of Alpha exposed household contacts. The odds of infection doubled with exposure to an index diagnosed with Alpha. There was evidence of transmission events in almost all households. Our data strongly support that estimates of SAR should include serological data to improve accuracy and understanding. Public Library of Science 2023-04-24 /pmc/articles/PMC10124829/ /pubmed/37093796 http://dx.doi.org/10.1371/journal.pone.0284372 Text en © 2023 Gaskell et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gaskell, Katherine M.
El Kheir, Natalie
Mirfendesky, Mariyam
Rampling, Tommy
Marks, Michael
Houlihan, Catherine F.
Lemonge, Norbert
Bristowe, Hannah
Aslam, Suhail
Kyprianou, Demetra
Nastouli, Eleni
Goldblatt, David
Fielding, Katherine
Moore, David A. J.
Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title_full Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title_fullStr Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title_full_unstemmed Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title_short Comparison of new and emerging SARS-CoV-2 variant transmissibility through active contact testing. A comparative cross-sectional household seroprevalence study
title_sort comparison of new and emerging sars-cov-2 variant transmissibility through active contact testing. a comparative cross-sectional household seroprevalence study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124829/
https://www.ncbi.nlm.nih.gov/pubmed/37093796
http://dx.doi.org/10.1371/journal.pone.0284372
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