Measurement of renal cortical fibrosis by CT scan

RATIONALE AND OBJECTIVES: The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases. MAT...

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Detalles Bibliográficos
Autores principales: Olson, John D, Tooze, Janet A, Bourland, Daniel J, Cline, J Mark, Faria, Eduardo B, Cohen, Eric P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124964/
https://www.ncbi.nlm.nih.gov/pubmed/37155521
http://dx.doi.org/10.1016/j.redii.2023.100024
Descripción
Sumario:RATIONALE AND OBJECTIVES: The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases. MATERIALS AND METHODS: We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis. RESULTS: Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis. CONCLUSION: Our method is suitable for immediate translation to human clinical renal diseases.

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