Safety and immunogenicity of a modified COVID-19 mRNA vaccine, SW-BIC-213, as a heterologous booster in healthy adults: an open-labeled, two-centered and multi-arm randomised, phase 1 trial

BACKGROUND: We assessed the safety and immunogenicity of a core–shell structured lipopolyplex (LPP) based COVID-19 mRNA vaccine, SW-BIC-213, as a heterologous booster in healthy adults. METHODS: We conducted an open-labeled, two-centered, and three-arm randomised phase 1 trial. Healthy adults, who h...

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Detalles Bibliográficos
Autores principales: Gui, Yu-Zhou, Li, Xue-Ning, Li, Jing-Xin, Shen, Ming-Yun, Zhang, Mei-Wei, Cao, Ye, Xu, Hong-Rong, Li, Hui, Cheng, Jie, Pan, Liang, Yi, Ying-Lei, Liang, Li-Yu, Yu, Cheng-Yin, Liu, Gang-Yi, Yu, Chen, Hu, Bi-Jie, Zhu, Feng-Cai, Liang, Fei, Shen, Haifa, Jia, Jing-Ying, Li, Hang-Wen, Zhou, Jian, Fan, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124970/
https://www.ncbi.nlm.nih.gov/pubmed/37099843
http://dx.doi.org/10.1016/j.ebiom.2023.104586

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