Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods

Mesenchymal stromal/stem cells (MSCs) derived from perinatal tissues have become indispensable sources for clinical applications due to their superior properties, ease of accessibility and minimal ethical concerns. MSCs isolated from different placenta (PL) and umbilical cord (UC) compartments exhib...

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Detalles Bibliográficos
Autores principales: Teoh, Peik Lin, Mohd Akhir, Haselamirrah, Abdul Ajak, Warda, Hiew, Vun Vun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125235/
https://www.ncbi.nlm.nih.gov/pubmed/37102047
http://dx.doi.org/10.21315/mjms2023.30.2.5
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author Teoh, Peik Lin
Mohd Akhir, Haselamirrah
Abdul Ajak, Warda
Hiew, Vun Vun
author_facet Teoh, Peik Lin
Mohd Akhir, Haselamirrah
Abdul Ajak, Warda
Hiew, Vun Vun
author_sort Teoh, Peik Lin
collection PubMed
description Mesenchymal stromal/stem cells (MSCs) derived from perinatal tissues have become indispensable sources for clinical applications due to their superior properties, ease of accessibility and minimal ethical concerns. MSCs isolated from different placenta (PL) and umbilical cord (UC) compartments exhibit great potential for stem cell-based therapies. However, their biological activities could vary due to tissue origins and differences in differentiation potentials. This review provides an overview of MSCs derived from various compartments of perinatal tissues, their characteristics and current isolation methods. Factors affecting the yield and purity of MSCs are also discussed as they are important to ensure consistent and unlimited supply for regenerative medicine and tissue engineering.
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spelling pubmed-101252352023-04-25 Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods Teoh, Peik Lin Mohd Akhir, Haselamirrah Abdul Ajak, Warda Hiew, Vun Vun Malays J Med Sci Review Article Mesenchymal stromal/stem cells (MSCs) derived from perinatal tissues have become indispensable sources for clinical applications due to their superior properties, ease of accessibility and minimal ethical concerns. MSCs isolated from different placenta (PL) and umbilical cord (UC) compartments exhibit great potential for stem cell-based therapies. However, their biological activities could vary due to tissue origins and differences in differentiation potentials. This review provides an overview of MSCs derived from various compartments of perinatal tissues, their characteristics and current isolation methods. Factors affecting the yield and purity of MSCs are also discussed as they are important to ensure consistent and unlimited supply for regenerative medicine and tissue engineering. Penerbit Universiti Sains Malaysia 2023-04 2023-04-18 /pmc/articles/PMC10125235/ /pubmed/37102047 http://dx.doi.org/10.21315/mjms2023.30.2.5 Text en © Penerbit Universiti Sains Malaysia, 2023 https://creativecommons.org/licenses/by/4.0/This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review Article
Teoh, Peik Lin
Mohd Akhir, Haselamirrah
Abdul Ajak, Warda
Hiew, Vun Vun
Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title_full Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title_fullStr Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title_full_unstemmed Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title_short Human Mesenchymal Stromal Cells Derived from Perinatal Tissues: Sources, Characteristics and Isolation Methods
title_sort human mesenchymal stromal cells derived from perinatal tissues: sources, characteristics and isolation methods
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125235/
https://www.ncbi.nlm.nih.gov/pubmed/37102047
http://dx.doi.org/10.21315/mjms2023.30.2.5
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