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Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective

The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillanc...

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Autores principales: Junaidi, Nor Syaza Syahirah Amat, Shakrin, Nik Noorul Shakira Mohamed, Desa, Mohd Nasir Mohd, Yunus, Wan Md Zin Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125240/
https://www.ncbi.nlm.nih.gov/pubmed/37102054
http://dx.doi.org/10.21315/mjms2023.30.2.3
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author Junaidi, Nor Syaza Syahirah Amat
Shakrin, Nik Noorul Shakira Mohamed
Desa, Mohd Nasir Mohd
Yunus, Wan Md Zin Wan
author_facet Junaidi, Nor Syaza Syahirah Amat
Shakrin, Nik Noorul Shakira Mohamed
Desa, Mohd Nasir Mohd
Yunus, Wan Md Zin Wan
author_sort Junaidi, Nor Syaza Syahirah Amat
collection PubMed
description The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia.
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spelling pubmed-101252402023-04-25 Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective Junaidi, Nor Syaza Syahirah Amat Shakrin, Nik Noorul Shakira Mohamed Desa, Mohd Nasir Mohd Yunus, Wan Md Zin Wan Malays J Med Sci Review Article The global emergence of methicillin-resistant Staphylococcus aureus (MRSA) that unsusceptible to a wide selection of antimicrobial agents and any newly introduced antimicrobial over the past decades has triggered more extensive holistic measures to put an end to this situation. Molecular surveillance of MRSA clones is important to understand their evolutionary dynamics for investigating outbreaks, propagating precautionary measures, as well as planning for appropriate treatment. This review includes peer-reviewed reports on the molecular characterisation of clinical Staphylococcus aureus isolates within Malaysian hospitals from year 2008 to 2020. This work highlights the molecular clones of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) isolates from Malaysian hospitals, with description on their ever-changing pattern. Among HA-MRSA, the ST22-t032-SCCmec IV MRSA clone was reported to supplant the previous dominating clone, ST239-t037-SCCmec III. Meanwhile, ST30, ST772, ST6 and ST22 were repeatedly detected in CA-MRSA, however, none of the strains became predominant. Future in-depth study on molecular epidemiology of MRSA clone is essential for the investigation of the extent of the clonal shift, especially in Malaysia. Penerbit Universiti Sains Malaysia 2023-04 2023-04-18 /pmc/articles/PMC10125240/ /pubmed/37102054 http://dx.doi.org/10.21315/mjms2023.30.2.3 Text en © Penerbit Universiti Sains Malaysia, 2023 https://creativecommons.org/licenses/by/4.0/This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review Article
Junaidi, Nor Syaza Syahirah Amat
Shakrin, Nik Noorul Shakira Mohamed
Desa, Mohd Nasir Mohd
Yunus, Wan Md Zin Wan
Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title_full Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title_fullStr Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title_full_unstemmed Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title_short Dissemination Pattern of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus and Community-Acquired MRSA Isolates from Malaysian Hospitals: A Review from a Molecular Perspective
title_sort dissemination pattern of hospital-acquired methicillin-resistant staphylococcus aureus and community-acquired mrsa isolates from malaysian hospitals: a review from a molecular perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125240/
https://www.ncbi.nlm.nih.gov/pubmed/37102054
http://dx.doi.org/10.21315/mjms2023.30.2.3
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