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Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea

[Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis...

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Autores principales: Tung, Nguyen Thanh, Lin, Shang-Yang, Liu, Wen-Te, Kuan, Yi-Chun, Wu, Chih-Da, Xuan Thao, Huynh Nguyen, Dung, Hoang Ba, Chung Thuy, Tran Phan, Chuang, Hsiao-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125288/
https://www.ncbi.nlm.nih.gov/pubmed/37101840
http://dx.doi.org/10.1021/acsenvironau.2c00034
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author Tung, Nguyen Thanh
Lin, Shang-Yang
Liu, Wen-Te
Kuan, Yi-Chun
Wu, Chih-Da
Xuan Thao, Huynh Nguyen
Dung, Hoang Ba
Chung Thuy, Tran Phan
Chuang, Hsiao-Chi
author_facet Tung, Nguyen Thanh
Lin, Shang-Yang
Liu, Wen-Te
Kuan, Yi-Chun
Wu, Chih-Da
Xuan Thao, Huynh Nguyen
Dung, Hoang Ba
Chung Thuy, Tran Phan
Chuang, Hsiao-Chi
author_sort Tung, Nguyen Thanh
collection PubMed
description [Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM(2.5) was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m(3)) of PM(2.5) was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA (p < 0.05). We observed that a 1 μg/m(3) increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) (p < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region (p < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA.
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spelling pubmed-101252882023-04-25 Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea Tung, Nguyen Thanh Lin, Shang-Yang Liu, Wen-Te Kuan, Yi-Chun Wu, Chih-Da Xuan Thao, Huynh Nguyen Dung, Hoang Ba Chung Thuy, Tran Phan Chuang, Hsiao-Chi ACS Environ Au [Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM(2.5) was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m(3)) of PM(2.5) was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA (p < 0.05). We observed that a 1 μg/m(3) increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) (p < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region (p < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA. American Chemical Society 2022-09-23 /pmc/articles/PMC10125288/ /pubmed/37101840 http://dx.doi.org/10.1021/acsenvironau.2c00034 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Tung, Nguyen Thanh
Lin, Shang-Yang
Liu, Wen-Te
Kuan, Yi-Chun
Wu, Chih-Da
Xuan Thao, Huynh Nguyen
Dung, Hoang Ba
Chung Thuy, Tran Phan
Chuang, Hsiao-Chi
Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title_full Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title_fullStr Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title_full_unstemmed Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title_short Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
title_sort higher particulate matter deposition in alveolar region could accelerate body fat accumulation in obstructive sleep apnea
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125288/
https://www.ncbi.nlm.nih.gov/pubmed/37101840
http://dx.doi.org/10.1021/acsenvironau.2c00034
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