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Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea
[Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125288/ https://www.ncbi.nlm.nih.gov/pubmed/37101840 http://dx.doi.org/10.1021/acsenvironau.2c00034 |
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author | Tung, Nguyen Thanh Lin, Shang-Yang Liu, Wen-Te Kuan, Yi-Chun Wu, Chih-Da Xuan Thao, Huynh Nguyen Dung, Hoang Ba Chung Thuy, Tran Phan Chuang, Hsiao-Chi |
author_facet | Tung, Nguyen Thanh Lin, Shang-Yang Liu, Wen-Te Kuan, Yi-Chun Wu, Chih-Da Xuan Thao, Huynh Nguyen Dung, Hoang Ba Chung Thuy, Tran Phan Chuang, Hsiao-Chi |
author_sort | Tung, Nguyen Thanh |
collection | PubMed |
description | [Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM(2.5) was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m(3)) of PM(2.5) was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA (p < 0.05). We observed that a 1 μg/m(3) increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) (p < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region (p < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA. |
format | Online Article Text |
id | pubmed-10125288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101252882023-04-25 Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea Tung, Nguyen Thanh Lin, Shang-Yang Liu, Wen-Te Kuan, Yi-Chun Wu, Chih-Da Xuan Thao, Huynh Nguyen Dung, Hoang Ba Chung Thuy, Tran Phan Chuang, Hsiao-Chi ACS Environ Au [Image: see text] We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM(2.5)) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM(2.5) was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m(3)) of PM(2.5) was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA (p < 0.05). We observed that a 1 μg/m(3) increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) (p < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region (p < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA. American Chemical Society 2022-09-23 /pmc/articles/PMC10125288/ /pubmed/37101840 http://dx.doi.org/10.1021/acsenvironau.2c00034 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Tung, Nguyen Thanh Lin, Shang-Yang Liu, Wen-Te Kuan, Yi-Chun Wu, Chih-Da Xuan Thao, Huynh Nguyen Dung, Hoang Ba Chung Thuy, Tran Phan Chuang, Hsiao-Chi Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title | Higher Particulate Matter Deposition in Alveolar Region
Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title_full | Higher Particulate Matter Deposition in Alveolar Region
Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title_fullStr | Higher Particulate Matter Deposition in Alveolar Region
Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title_full_unstemmed | Higher Particulate Matter Deposition in Alveolar Region
Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title_short | Higher Particulate Matter Deposition in Alveolar Region
Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea |
title_sort | higher particulate matter deposition in alveolar region
could accelerate body fat accumulation in obstructive sleep apnea |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125288/ https://www.ncbi.nlm.nih.gov/pubmed/37101840 http://dx.doi.org/10.1021/acsenvironau.2c00034 |
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