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Modeling the Effect of Cooperativity in Ternary Complex Formation and Targeted Protein Degradation Mediated by Heterobifunctional Degraders

[Image: see text] Chemically induced proximity between certain endogenous enzymes and a protein of interest (POI) inside cells may cause post-translational modifications to the POI with biological consequences and potential therapeutic effects. Heterobifunctional (HBF) molecules that bind with one f...

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Detalles Bibliográficos
Autores principales:	Park, Daniel, Izaguirre, Jesus, Coffey, Rory, Xu, Huafeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125322/ https://www.ncbi.nlm.nih.gov/pubmed/37101604 http://dx.doi.org/10.1021/acsbiomedchemau.2c00037

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