Cargando…

Curcumin Improves Diabetic Cardiomyopathy by Inhibiting Pyroptosis through AKT/Nrf2/ARE Pathway

This study is aimed at exploring whether curcumin can regulate the AKT pathway, promote the transfer of Nrf2 into the nucleus, and inhibit cell pyroptosis in diabetic cardiomyopathy. Diabetic rats and cardiomyocytes were treated with curcumin to study its effect on myocardial pyroptosis. Whether cur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Zhang, pinfang, Kang, jing, Zhou, zhuoya, Yao, Shaohuan, Qian, Chao, Shi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125772/ https://www.ncbi.nlm.nih.gov/pubmed/37101595 http://dx.doi.org/10.1155/2023/3906043

Ejemplares similares

Quercetin Inhibits Pyroptosis in Diabetic Cardiomyopathy through the Nrf2 Pathway
por: Wei, Zhang, et al.
Publicado: (2022)

Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway
por: Wei, Zhang, et al.
Publicado: (2022)

Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation
por: Zhang, Wei, et al.
Publicado: (2023)

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway
por: Wu, Jingxian, et al.
Publicado: (2013)

Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats
por: Yin, Yiyu, et al.
Publicado: (2020)

Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway
por: Xiong, Yixuan, et al.
Publicado: (2020)

Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway
por: Li, Fan, et al.
Publicado: (2023)

CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway
por: Zhang, Ting, et al.
Publicado: (2023)

Kynurenic acid inhibits macrophage pyroptosis by suppressing ROS production via activation of the NRF2 pathway
por: Gao, Yuwei, et al.
Publicado: (2023)

Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways
por: Ren, Bin‐cheng, et al.
Publicado: (2020)

CD38 Deficiency Alleviates Diabetic Cardiomyopathy by Coordinately Inhibiting Pyroptosis and Apoptosis
por: Wang, Ling-Fang, et al.
Publicado: (2023)

Pomiferin Exerts Antineuroinflammatory Effects through Activating Akt/Nrf2 Pathway and Inhibiting NF-κB Pathway
por: Zhao, Yan, et al.
Publicado: (2022)

Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway
por: Sun, Huanhuan, et al.
Publicado: (2022)

Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling
por: Lin, Yuqing, et al.
Publicado: (2020)

Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
por: Lu, Yafang, et al.
Publicado: (2022)

Potential diabetic cardiomyopathy therapies targeting pyroptosis: A mini review
por: Jia, Yu, et al.
Publicado: (2022)

PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψ(m) Pathways by Inhibiting Pyroptosis
por: Feng, Zhencheng, et al.
Publicado: (2023)

Expression of miRNAs in plasma exosomes derived from patients with atrial fibrillation
por: Wei, Zhang, et al.
Publicado: (2020)

Curcumin improves the function of umbilical vein endothelial cells by inhibiting H(2)O(2)-induced pyroptosis
por: Yuan, Yulin, et al.
Publicado: (2022)

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
por: Zhao, Dong, et al.
Publicado: (2019)

Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis
por: Huang, Yongzhou, et al.
Publicado: (2023)

Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway
por: Wang, Yanqiu, et al.
Publicado: (2019)

Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy
por: Cai, Zhengyao, et al.
Publicado: (2022)

Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs
por: Yan, Enfa, et al.
Publicado: (2019)

Exogenous spermine inhibits high glucose/oxidized LDL-induced oxidative stress and macrophage pyroptosis by activating the Nrf2 pathway
por: Qiu, Yuxuan, et al.
Publicado: (2022)

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway
por: Huang, Cancan, et al.
Publicado: (2020)

Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell
por: Wang, Xinzheng, et al.
Publicado: (2017)

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway
por: Zhang, Qianqian, et al.
Publicado: (2023)

Nrf2 Inhibits the Progression of Parkinson’s Disease by Upregulating AABR07032261.5 to Repress Pyroptosis
por: Zhong, Yunxiao, et al.
Publicado: (2022)

Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT
por: CHEN, MING-HO, et al.
Publicado: (2012)

Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications
por: Shi, Yi, et al.
Publicado: (2023)

Emodin Ameliorates Acute Pancreatitis-Associated Lung Injury Through Inhibiting the Alveolar Macrophages Pyroptosis
por: Wu, Xiajia, et al.
Publicado: (2022)

Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation
por: Li, Danlei, et al.
Publicado: (2022)

Pyrroloquinoline quinone ameliorates diabetic cardiomyopathy by inhibiting the pyroptosis signaling pathway in C57BL/6 mice and AC16 cells
por: Qu, Xue-feng, et al.
Publicado: (2022)

Ginsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling
por: Yao, Yueyi, et al.
Publicado: (2021)

Dioscin Improves Pyroptosis in LPS-Induced Mice Mastitis by Activating AMPK/Nrf2 and Inhibiting the NF-κB Signaling Pathway
por: Ran, Xin, et al.
Publicado: (2020)

Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation
por: Wang, Xuebin, et al.
Publicado: (2023)

AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes‐related osteoporosis by activating Nrf2/Keap1 pathway
por: Fu, Fangda, et al.
Publicado: (2023)

Citrulline protects against LPS‑induced acute lung injury by inhibiting ROS/NLRP3‑dependent pyroptosis and apoptosis via the Nrf2 signaling pathway
por: Xue, Yao, et al.
Publicado: (2022)

Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways
por: Liao, Dehua, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_al8enlnl8k78cpp11quoq4sqa1