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Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recent...

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Detalles Bibliográficos
Autores principales: Li, Zhangfu, Yang, Honghao, Hai, Yong, Cheng, Yunzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125773/
https://www.ncbi.nlm.nih.gov/pubmed/37101594
http://dx.doi.org/10.1155/2023/6210885
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author Li, Zhangfu
Yang, Honghao
Hai, Yong
Cheng, Yunzhong
author_facet Li, Zhangfu
Yang, Honghao
Hai, Yong
Cheng, Yunzhong
author_sort Li, Zhangfu
collection PubMed
description Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described.
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spelling pubmed-101257732023-04-25 Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration Li, Zhangfu Yang, Honghao Hai, Yong Cheng, Yunzhong Mediators Inflamm Review Article Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described. Hindawi 2023-04-17 /pmc/articles/PMC10125773/ /pubmed/37101594 http://dx.doi.org/10.1155/2023/6210885 Text en Copyright © 2023 Zhangfu Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Zhangfu
Yang, Honghao
Hai, Yong
Cheng, Yunzhong
Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title_full Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title_fullStr Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title_full_unstemmed Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title_short Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration
title_sort regulatory effect of inflammatory mediators in intervertebral disc degeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125773/
https://www.ncbi.nlm.nih.gov/pubmed/37101594
http://dx.doi.org/10.1155/2023/6210885
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