Cargando…
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules
BACKGROUND: Previous studies have suggested the applicability of three classifications of subsolid nodules (SSNs). However, few studies have unraveled the natural history of the three types of SSNs. METHODS: A retrospective study from two medical centers between November 2007 and November 2017 was c...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125786/ https://www.ncbi.nlm.nih.gov/pubmed/36922372 http://dx.doi.org/10.1111/1759-7714.14845 |
_version_ | 1785030099215581184 |
---|---|
author | Zhang, Zhedong Zhou, Lixin Min, Xianjun Li, Hao Qi, Qingyi Sun, Chao Sun, Kunkun Yang, Fan Li, Xiao |
author_facet | Zhang, Zhedong Zhou, Lixin Min, Xianjun Li, Hao Qi, Qingyi Sun, Chao Sun, Kunkun Yang, Fan Li, Xiao |
author_sort | Zhang, Zhedong |
collection | PubMed |
description | BACKGROUND: Previous studies have suggested the applicability of three classifications of subsolid nodules (SSNs). However, few studies have unraveled the natural history of the three types of SSNs. METHODS: A retrospective study from two medical centers between November 2007 and November 2017 was conducted to explore the long‐term follow‐up results of three different types of SSNs, which were divided into pure ground‐glass nodules (pGGNs), heterogeneous ground‐glass nodules (hGGNs), and real part‐solid nodules (rPSNs). RESULTS: A total of 306 consecutive patients, including 361 SSNs with long‐term follow‐up, were reviewed. The median growth times of pGGNs, hGGNs, and rPSNs were 7.7, 6.0, and 2.0 years, respectively. For pGGNs, the median period of development into rPSNs was 4.6 years, while that of hGGNs was 1.8 years, and the time from pGGNs to hGGNs was 3.1 years (p < 0.05). In SSNs with an initial lung window consolidation tumor ratio (LW‐CTR) >0.5 and mediastinum window (MW)‐CTR >0.2, all cases with growth were identified within 5 years. Meanwhile, in SSNs whose LW‐CTR and MW‐CTR were 0, it took over 5 years to detect nodular growth. Pathologically, 90.6% of initial SSNs with LW‐CTR >0 were invasive carcinomas (invasive adenocarcinoma and micro‐invasive adenocarcinoma). Among patients with rPSNs in the initial state, 100.0% of the final pathological results were invasive carcinoma. Cox regression showed that age (p = 0.038), initial maximal diameter (p < 0.001), and LW‐CTR (p = 0.002) were independent risk factors for SSN growth. CONCLUSIONS: pGGNs, hGGNs, and rPSNs have significantly different natural histories. Age, initial nodule diameter, and LW‐CTR are important risk factors for SSN growth. |
format | Online Article Text |
id | pubmed-10125786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-101257862023-04-25 Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules Zhang, Zhedong Zhou, Lixin Min, Xianjun Li, Hao Qi, Qingyi Sun, Chao Sun, Kunkun Yang, Fan Li, Xiao Thorac Cancer Original Articles BACKGROUND: Previous studies have suggested the applicability of three classifications of subsolid nodules (SSNs). However, few studies have unraveled the natural history of the three types of SSNs. METHODS: A retrospective study from two medical centers between November 2007 and November 2017 was conducted to explore the long‐term follow‐up results of three different types of SSNs, which were divided into pure ground‐glass nodules (pGGNs), heterogeneous ground‐glass nodules (hGGNs), and real part‐solid nodules (rPSNs). RESULTS: A total of 306 consecutive patients, including 361 SSNs with long‐term follow‐up, were reviewed. The median growth times of pGGNs, hGGNs, and rPSNs were 7.7, 6.0, and 2.0 years, respectively. For pGGNs, the median period of development into rPSNs was 4.6 years, while that of hGGNs was 1.8 years, and the time from pGGNs to hGGNs was 3.1 years (p < 0.05). In SSNs with an initial lung window consolidation tumor ratio (LW‐CTR) >0.5 and mediastinum window (MW)‐CTR >0.2, all cases with growth were identified within 5 years. Meanwhile, in SSNs whose LW‐CTR and MW‐CTR were 0, it took over 5 years to detect nodular growth. Pathologically, 90.6% of initial SSNs with LW‐CTR >0 were invasive carcinomas (invasive adenocarcinoma and micro‐invasive adenocarcinoma). Among patients with rPSNs in the initial state, 100.0% of the final pathological results were invasive carcinoma. Cox regression showed that age (p = 0.038), initial maximal diameter (p < 0.001), and LW‐CTR (p = 0.002) were independent risk factors for SSN growth. CONCLUSIONS: pGGNs, hGGNs, and rPSNs have significantly different natural histories. Age, initial nodule diameter, and LW‐CTR are important risk factors for SSN growth. John Wiley & Sons Australia, Ltd 2023-03-15 /pmc/articles/PMC10125786/ /pubmed/36922372 http://dx.doi.org/10.1111/1759-7714.14845 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Zhang, Zhedong Zhou, Lixin Min, Xianjun Li, Hao Qi, Qingyi Sun, Chao Sun, Kunkun Yang, Fan Li, Xiao Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title |
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title_full |
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title_fullStr |
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title_full_unstemmed |
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title_short |
Long‐term follow‐up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
title_sort | long‐term follow‐up of persistent pulmonary subsolid nodules: natural course of pure, heterogeneous, and real part‐solid ground‐glass nodules |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125786/ https://www.ncbi.nlm.nih.gov/pubmed/36922372 http://dx.doi.org/10.1111/1759-7714.14845 |
work_keys_str_mv | AT zhangzhedong longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT zhoulixin longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT minxianjun longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT lihao longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT qiqingyi longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT sunchao longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT sunkunkun longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT yangfan longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules AT lixiao longtermfollowupofpersistentpulmonarysubsolidnodulesnaturalcourseofpureheterogeneousandrealpartsolidgroundglassnodules |