Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report

Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC,...

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Autores principales: Kohya, Risako, Sugiura, Ryo, Yamamoto, Yoshiya, Naruse, Hirohito, Hatanaka, Kazuteru, Kinoshita, Kenji, Abiko, Satoshi, Miyamoto, Shuichi, Suzuki, Kazuharu, Kushibiki, Hanae, Munakata, Satoru, Shimoyama, Norihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125806/
https://www.ncbi.nlm.nih.gov/pubmed/36047124
http://dx.doi.org/10.2169/internalmedicine.0114-22
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author Kohya, Risako
Sugiura, Ryo
Yamamoto, Yoshiya
Naruse, Hirohito
Hatanaka, Kazuteru
Kinoshita, Kenji
Abiko, Satoshi
Miyamoto, Shuichi
Suzuki, Kazuharu
Kushibiki, Hanae
Munakata, Satoru
Shimoyama, Norihiko
author_facet Kohya, Risako
Sugiura, Ryo
Yamamoto, Yoshiya
Naruse, Hirohito
Hatanaka, Kazuteru
Kinoshita, Kenji
Abiko, Satoshi
Miyamoto, Shuichi
Suzuki, Kazuharu
Kushibiki, Hanae
Munakata, Satoru
Shimoyama, Norihiko
author_sort Kohya, Risako
collection PubMed
description Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.
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spelling pubmed-101258062023-04-26 Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report Kohya, Risako Sugiura, Ryo Yamamoto, Yoshiya Naruse, Hirohito Hatanaka, Kazuteru Kinoshita, Kenji Abiko, Satoshi Miyamoto, Shuichi Suzuki, Kazuharu Kushibiki, Hanae Munakata, Satoru Shimoyama, Norihiko Intern Med Case Report Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib. The Japanese Society of Internal Medicine 2022-08-30 2023-04-01 /pmc/articles/PMC10125806/ /pubmed/36047124 http://dx.doi.org/10.2169/internalmedicine.0114-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kohya, Risako
Sugiura, Ryo
Yamamoto, Yoshiya
Naruse, Hirohito
Hatanaka, Kazuteru
Kinoshita, Kenji
Abiko, Satoshi
Miyamoto, Shuichi
Suzuki, Kazuharu
Kushibiki, Hanae
Munakata, Satoru
Shimoyama, Norihiko
Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title_full Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title_fullStr Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title_full_unstemmed Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title_short Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report
title_sort hepatocellular carcinoma rupture after introducing lenvatinib: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125806/
https://www.ncbi.nlm.nih.gov/pubmed/36047124
http://dx.doi.org/10.2169/internalmedicine.0114-22
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