Copper Deficiency in Wilson's Disease with a Normal Zinc Value

Copper deficiency (CD) is a rare complication of long-term treatment of Wilson's disease (WD) and is usually accompanied by high serum zinc levels. A 57-year-old woman with WD presented with limb weakness and sensory disturbance due to myeloneuropathy and macrocytic anemia after 36 years of tre...

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Autores principales: Ueda, Masayuki, Katsuse, Kazuto, Kakumoto, Toshiyuki, Kobayashi, Satoshi, Ishiura, Hiroyuki, Mitsui, Jun, Toda, Tatsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125822/
https://www.ncbi.nlm.nih.gov/pubmed/36047117
http://dx.doi.org/10.2169/internalmedicine.9366-22
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author Ueda, Masayuki
Katsuse, Kazuto
Kakumoto, Toshiyuki
Kobayashi, Satoshi
Ishiura, Hiroyuki
Mitsui, Jun
Toda, Tatsushi
author_facet Ueda, Masayuki
Katsuse, Kazuto
Kakumoto, Toshiyuki
Kobayashi, Satoshi
Ishiura, Hiroyuki
Mitsui, Jun
Toda, Tatsushi
author_sort Ueda, Masayuki
collection PubMed
description Copper deficiency (CD) is a rare complication of long-term treatment of Wilson's disease (WD) and is usually accompanied by high serum zinc levels. A 57-year-old woman with WD presented with limb weakness and sensory disturbance due to myeloneuropathy and macrocytic anemia after 36 years of treatment. Markedly reduced serum free copper values confirmed CD, which was considered to be caused by progressive dysphagia and severe diarrhea rather than zinc overdose because of the normal serum zinc levels. Discontinuing copper-reducing therapy and increasing copper intake improved her symptoms. Physicians should be alert for the risk of CD in WD patients, especially those with dysphagia.
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spelling pubmed-101258222023-04-26 Copper Deficiency in Wilson's Disease with a Normal Zinc Value Ueda, Masayuki Katsuse, Kazuto Kakumoto, Toshiyuki Kobayashi, Satoshi Ishiura, Hiroyuki Mitsui, Jun Toda, Tatsushi Intern Med Case Report Copper deficiency (CD) is a rare complication of long-term treatment of Wilson's disease (WD) and is usually accompanied by high serum zinc levels. A 57-year-old woman with WD presented with limb weakness and sensory disturbance due to myeloneuropathy and macrocytic anemia after 36 years of treatment. Markedly reduced serum free copper values confirmed CD, which was considered to be caused by progressive dysphagia and severe diarrhea rather than zinc overdose because of the normal serum zinc levels. Discontinuing copper-reducing therapy and increasing copper intake improved her symptoms. Physicians should be alert for the risk of CD in WD patients, especially those with dysphagia. The Japanese Society of Internal Medicine 2022-08-30 2023-04-01 /pmc/articles/PMC10125822/ /pubmed/36047117 http://dx.doi.org/10.2169/internalmedicine.9366-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ueda, Masayuki
Katsuse, Kazuto
Kakumoto, Toshiyuki
Kobayashi, Satoshi
Ishiura, Hiroyuki
Mitsui, Jun
Toda, Tatsushi
Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title_full Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title_fullStr Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title_full_unstemmed Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title_short Copper Deficiency in Wilson's Disease with a Normal Zinc Value
title_sort copper deficiency in wilson's disease with a normal zinc value
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125822/
https://www.ncbi.nlm.nih.gov/pubmed/36047117
http://dx.doi.org/10.2169/internalmedicine.9366-22
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