Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review

We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antir...

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Detalles Bibliográficos
Autores principales: Akagi, Yu, Tanaka, Kosuke, Mawatari, Momoko, Toda, Yuta, Kumasaka, Toshio, Ueda, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125823/
https://www.ncbi.nlm.nih.gov/pubmed/37005296
http://dx.doi.org/10.2169/internalmedicine.9661-22
Descripción
Sumario:We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antiretroviral therapy. They were usually accompanied by both a significant decrease in CD4 count (median 292 /μL) and a rapid increase in plasma human immunodeficiency virus loads (median 3.5×10(5)/mL). Although life-threatening complications were reported, the overall prognosis was favorable. The outcomes of this review aided in the diagnosis of the present case.

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