Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review

We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antir...

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Autores principales: Akagi, Yu, Tanaka, Kosuke, Mawatari, Momoko, Toda, Yuta, Kumasaka, Toshio, Ueda, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125823/
https://www.ncbi.nlm.nih.gov/pubmed/37005296
http://dx.doi.org/10.2169/internalmedicine.9661-22
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author Akagi, Yu
Tanaka, Kosuke
Mawatari, Momoko
Toda, Yuta
Kumasaka, Toshio
Ueda, Akihiro
author_facet Akagi, Yu
Tanaka, Kosuke
Mawatari, Momoko
Toda, Yuta
Kumasaka, Toshio
Ueda, Akihiro
author_sort Akagi, Yu
collection PubMed
description We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antiretroviral therapy. They were usually accompanied by both a significant decrease in CD4 count (median 292 /μL) and a rapid increase in plasma human immunodeficiency virus loads (median 3.5×10(5)/mL). Although life-threatening complications were reported, the overall prognosis was favorable. The outcomes of this review aided in the diagnosis of the present case.
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spelling pubmed-101258232023-04-26 Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review Akagi, Yu Tanaka, Kosuke Mawatari, Momoko Toda, Yuta Kumasaka, Toshio Ueda, Akihiro Intern Med Case Report We herein report a case of retroviral rebound syndrome (RRS) complicated with hemophagocytic lymphohistiocytosis. Owing to the paucity of comprehensive data on RRS, we also conducted a literature review. All 19 cases included in the review presented within 2 months after the discontinuation of antiretroviral therapy. They were usually accompanied by both a significant decrease in CD4 count (median 292 /μL) and a rapid increase in plasma human immunodeficiency virus loads (median 3.5×10(5)/mL). Although life-threatening complications were reported, the overall prognosis was favorable. The outcomes of this review aided in the diagnosis of the present case. The Japanese Society of Internal Medicine 2023-04-01 2023-04-01 /pmc/articles/PMC10125823/ /pubmed/37005296 http://dx.doi.org/10.2169/internalmedicine.9661-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Akagi, Yu
Tanaka, Kosuke
Mawatari, Momoko
Toda, Yuta
Kumasaka, Toshio
Ueda, Akihiro
Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title_full Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title_fullStr Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title_full_unstemmed Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title_short Clinical Characteristics of Retroviral Rebound Syndrome: A Case Report and Literature Review
title_sort clinical characteristics of retroviral rebound syndrome: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125823/
https://www.ncbi.nlm.nih.gov/pubmed/37005296
http://dx.doi.org/10.2169/internalmedicine.9661-22
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