Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis

Systemic lupus erythematosus was diagnosed in a patient at 43 years old. When proteinuria recurred at 57 years old, the first kidney biopsy was performed, and class IV-G (A)+V lupus nephritis was diagnosed. The prednisolone dose was increased to 40 mg/day, and cyclosporine A was introduced. After 1...

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Detalles Bibliográficos
Autores principales: Sawamura, Masato, Sawa, Naoki, Ikuma, Daisuke, Oba, Yuki, Yamanouchi, Masayuki, Sekine, Akinari, Mizuno, Hiroki, Hasegawa, Eiko, Suwabe, Tatsuya, Hoshino, Junichi, Kono, Kei, Kinowaki, Keiichi, Ohashi, Kenichi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125829/
https://www.ncbi.nlm.nih.gov/pubmed/36070938
http://dx.doi.org/10.2169/internalmedicine.0160-22
Descripción
Sumario:Systemic lupus erythematosus was diagnosed in a patient at 43 years old. When proteinuria recurred at 57 years old, the first kidney biopsy was performed, and class IV-G (A)+V lupus nephritis was diagnosed. The prednisolone dose was increased to 40 mg/day, and cyclosporine A was introduced. After 1 year, proteinuria had decreased to 0.1 g/day. Prednisolone was discontinued three years later, and cyclosporine A was continued. Thereafter, proteinuria did not reoccur. At 67 years old, a second kidney biopsy showed complete remission of lupus nephritis. Cyclosporine A enabled permanent discontinuation of glucocorticoids in a patient with lupus nephritis.

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