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Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis

Systemic lupus erythematosus was diagnosed in a patient at 43 years old. When proteinuria recurred at 57 years old, the first kidney biopsy was performed, and class IV-G (A)+V lupus nephritis was diagnosed. The prednisolone dose was increased to 40 mg/day, and cyclosporine A was introduced. After 1...

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Autores principales: Sawamura, Masato, Sawa, Naoki, Ikuma, Daisuke, Oba, Yuki, Yamanouchi, Masayuki, Sekine, Akinari, Mizuno, Hiroki, Hasegawa, Eiko, Suwabe, Tatsuya, Hoshino, Junichi, Kono, Kei, Kinowaki, Keiichi, Ohashi, Kenichi, Ubara, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125829/
https://www.ncbi.nlm.nih.gov/pubmed/36070938
http://dx.doi.org/10.2169/internalmedicine.0160-22
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author Sawamura, Masato
Sawa, Naoki
Ikuma, Daisuke
Oba, Yuki
Yamanouchi, Masayuki
Sekine, Akinari
Mizuno, Hiroki
Hasegawa, Eiko
Suwabe, Tatsuya
Hoshino, Junichi
Kono, Kei
Kinowaki, Keiichi
Ohashi, Kenichi
Ubara, Yoshifumi
author_facet Sawamura, Masato
Sawa, Naoki
Ikuma, Daisuke
Oba, Yuki
Yamanouchi, Masayuki
Sekine, Akinari
Mizuno, Hiroki
Hasegawa, Eiko
Suwabe, Tatsuya
Hoshino, Junichi
Kono, Kei
Kinowaki, Keiichi
Ohashi, Kenichi
Ubara, Yoshifumi
author_sort Sawamura, Masato
collection PubMed
description Systemic lupus erythematosus was diagnosed in a patient at 43 years old. When proteinuria recurred at 57 years old, the first kidney biopsy was performed, and class IV-G (A)+V lupus nephritis was diagnosed. The prednisolone dose was increased to 40 mg/day, and cyclosporine A was introduced. After 1 year, proteinuria had decreased to 0.1 g/day. Prednisolone was discontinued three years later, and cyclosporine A was continued. Thereafter, proteinuria did not reoccur. At 67 years old, a second kidney biopsy showed complete remission of lupus nephritis. Cyclosporine A enabled permanent discontinuation of glucocorticoids in a patient with lupus nephritis.
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spelling pubmed-101258292023-04-26 Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis Sawamura, Masato Sawa, Naoki Ikuma, Daisuke Oba, Yuki Yamanouchi, Masayuki Sekine, Akinari Mizuno, Hiroki Hasegawa, Eiko Suwabe, Tatsuya Hoshino, Junichi Kono, Kei Kinowaki, Keiichi Ohashi, Kenichi Ubara, Yoshifumi Intern Med Case Report Systemic lupus erythematosus was diagnosed in a patient at 43 years old. When proteinuria recurred at 57 years old, the first kidney biopsy was performed, and class IV-G (A)+V lupus nephritis was diagnosed. The prednisolone dose was increased to 40 mg/day, and cyclosporine A was introduced. After 1 year, proteinuria had decreased to 0.1 g/day. Prednisolone was discontinued three years later, and cyclosporine A was continued. Thereafter, proteinuria did not reoccur. At 67 years old, a second kidney biopsy showed complete remission of lupus nephritis. Cyclosporine A enabled permanent discontinuation of glucocorticoids in a patient with lupus nephritis. The Japanese Society of Internal Medicine 2022-09-06 2023-04-01 /pmc/articles/PMC10125829/ /pubmed/36070938 http://dx.doi.org/10.2169/internalmedicine.0160-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sawamura, Masato
Sawa, Naoki
Ikuma, Daisuke
Oba, Yuki
Yamanouchi, Masayuki
Sekine, Akinari
Mizuno, Hiroki
Hasegawa, Eiko
Suwabe, Tatsuya
Hoshino, Junichi
Kono, Kei
Kinowaki, Keiichi
Ohashi, Kenichi
Ubara, Yoshifumi
Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title_full Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title_fullStr Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title_full_unstemmed Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title_short Successful Discontinuation of Glucocorticoid Treatment after Administration of a Calcineurin Inhibitor for Nephrotic Syndrome in a Patient with Lupus Nephritis
title_sort successful discontinuation of glucocorticoid treatment after administration of a calcineurin inhibitor for nephrotic syndrome in a patient with lupus nephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125829/
https://www.ncbi.nlm.nih.gov/pubmed/36070938
http://dx.doi.org/10.2169/internalmedicine.0160-22
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