Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (H(C)E) in complex with its neuronal receptor synaptic vesicle glycoprotein 2A (SV2...

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Detalles Bibliográficos
Autores principales: Liu, Zheng, Lee, Pyung-Gang, Krez, Nadja, Lam, Kwok-ho, Liu, Hao, Przykopanski, Adina, Chen, Peng, Yao, Guorui, Zhang, Sicai, Tremblay, Jacqueline M., Perry, Kay, Shoemaker, Charles B., Rummel, Andreas, Dong, Min, Jin, Rongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125960/
https://www.ncbi.nlm.nih.gov/pubmed/37095076
http://dx.doi.org/10.1038/s41467-023-37860-8

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