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Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry

BACKGROUND: Retinal oxygen saturation (sO(2)) provides essential information about the eye’s response to pathological changes that can result in vision loss. Visible-light optical coherence tomography (vis-OCT) is a noninvasive tool that has the potential to measure retinal sO(2) in a clinical setti...

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Autores principales: Rubinoff, Ian, Kuranov, Roman V., Fang, Raymond, Ghassabi, Zeinab, Wang, Yuanbo, Beckmann, Lisa, Miller, David A., Wollstein, Gadi, Ishikawa, Hiroshi, Schuman, Joel S., Zhang, Hao F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126115/
https://www.ncbi.nlm.nih.gov/pubmed/37095177
http://dx.doi.org/10.1038/s43856-023-00288-8
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author Rubinoff, Ian
Kuranov, Roman V.
Fang, Raymond
Ghassabi, Zeinab
Wang, Yuanbo
Beckmann, Lisa
Miller, David A.
Wollstein, Gadi
Ishikawa, Hiroshi
Schuman, Joel S.
Zhang, Hao F.
author_facet Rubinoff, Ian
Kuranov, Roman V.
Fang, Raymond
Ghassabi, Zeinab
Wang, Yuanbo
Beckmann, Lisa
Miller, David A.
Wollstein, Gadi
Ishikawa, Hiroshi
Schuman, Joel S.
Zhang, Hao F.
author_sort Rubinoff, Ian
collection PubMed
description BACKGROUND: Retinal oxygen saturation (sO(2)) provides essential information about the eye’s response to pathological changes that can result in vision loss. Visible-light optical coherence tomography (vis-OCT) is a noninvasive tool that has the potential to measure retinal sO(2) in a clinical setting. However, its reliability is currently limited by unwanted signals referred to as spectral contaminants (SCs), and a comprehensive strategy to isolate true oxygen-dependent signals from SCs in vis-OCT is lacking. METHODS: We develop an adaptive spectroscopic vis-OCT (ADS-vis-OCT) technique that can adaptively remove SCs and accurately measure sO(2) under the unique conditions of each vessel. We also validate the accuracy of ADS-vis-OCT using ex vivo blood phantoms and assess its repeatability in the retina of healthy volunteers. RESULTS: In ex vivo blood phantoms, ADS-vis-OCT agrees with a blood gas machine with only a 1% bias in samples with sO(2) ranging from 0% to 100%. In the human retina, the root mean squared error between sO(2) values in major arteries measured by ADS-vis-OCT and a pulse oximeter is 2.1% across 18 research participants. Additionally, the standard deviations of repeated ADS-vis-OCT measurements of sO(2) values in smaller arteries and veins are 2.5% and 2.3%, respectively. Non-adaptive methods do not achieve comparable repeatabilities from healthy volunteers. CONCLUSIONS: ADS-vis-OCT effectively removes SCs from human images, yielding accurate and repeatable sO(2) measurements in retinal arteries and veins with varying diameters. This work could have important implications for the clinical use of vis-OCT to manage eye diseases.
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spelling pubmed-101261152023-04-26 Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry Rubinoff, Ian Kuranov, Roman V. Fang, Raymond Ghassabi, Zeinab Wang, Yuanbo Beckmann, Lisa Miller, David A. Wollstein, Gadi Ishikawa, Hiroshi Schuman, Joel S. Zhang, Hao F. Commun Med (Lond) Article BACKGROUND: Retinal oxygen saturation (sO(2)) provides essential information about the eye’s response to pathological changes that can result in vision loss. Visible-light optical coherence tomography (vis-OCT) is a noninvasive tool that has the potential to measure retinal sO(2) in a clinical setting. However, its reliability is currently limited by unwanted signals referred to as spectral contaminants (SCs), and a comprehensive strategy to isolate true oxygen-dependent signals from SCs in vis-OCT is lacking. METHODS: We develop an adaptive spectroscopic vis-OCT (ADS-vis-OCT) technique that can adaptively remove SCs and accurately measure sO(2) under the unique conditions of each vessel. We also validate the accuracy of ADS-vis-OCT using ex vivo blood phantoms and assess its repeatability in the retina of healthy volunteers. RESULTS: In ex vivo blood phantoms, ADS-vis-OCT agrees with a blood gas machine with only a 1% bias in samples with sO(2) ranging from 0% to 100%. In the human retina, the root mean squared error between sO(2) values in major arteries measured by ADS-vis-OCT and a pulse oximeter is 2.1% across 18 research participants. Additionally, the standard deviations of repeated ADS-vis-OCT measurements of sO(2) values in smaller arteries and veins are 2.5% and 2.3%, respectively. Non-adaptive methods do not achieve comparable repeatabilities from healthy volunteers. CONCLUSIONS: ADS-vis-OCT effectively removes SCs from human images, yielding accurate and repeatable sO(2) measurements in retinal arteries and veins with varying diameters. This work could have important implications for the clinical use of vis-OCT to manage eye diseases. Nature Publishing Group UK 2023-04-24 /pmc/articles/PMC10126115/ /pubmed/37095177 http://dx.doi.org/10.1038/s43856-023-00288-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rubinoff, Ian
Kuranov, Roman V.
Fang, Raymond
Ghassabi, Zeinab
Wang, Yuanbo
Beckmann, Lisa
Miller, David A.
Wollstein, Gadi
Ishikawa, Hiroshi
Schuman, Joel S.
Zhang, Hao F.
Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title_full Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title_fullStr Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title_full_unstemmed Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title_short Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
title_sort adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126115/
https://www.ncbi.nlm.nih.gov/pubmed/37095177
http://dx.doi.org/10.1038/s43856-023-00288-8
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