Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs

Synthetic sRNAs allow knockdown of target genes at translational level, but have been restricted to a limited number of bacteria. Here, we report the development of a broad-host-range synthetic sRNA (BHR-sRNA) platform employing the RoxS scaffold and the Hfq chaperone from Bacillus subtilis. BHR-sRN...

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Detalles Bibliográficos
Autores principales: Cho, Jae Sung, Yang, Dongsoo, Prabowo, Cindy Pricilia Surya, Ghiffary, Mohammad Rifqi, Han, Taehee, Choi, Kyeong Rok, Moon, Cheon Woo, Zhou, Hengrui, Ryu, Jae Yong, Kim, Hyun Uk, Lee, Sang Yup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126203/
https://www.ncbi.nlm.nih.gov/pubmed/37095132
http://dx.doi.org/10.1038/s41467-023-38119-y

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