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The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task

BACKGROUND: Functional near-infrared spectroscopy (fNIRS) identifies neurophysiological differences between psychiatric disorders by assessing cortical hemodynamic function. Few trials have studied differences in brain functional activity between first-episode medication-naïve depression patients (F...

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Autores principales: Yang, Ting, Wang, Hongyu, Dai, Haiyue, Hui, Juan, Zhang, Jintong, Li, Juan, Cui, Guimei, Wang, Juan, Mu, Junlin, Zhang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126326/
https://www.ncbi.nlm.nih.gov/pubmed/37113544
http://dx.doi.org/10.3389/fpsyt.2023.1132666
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author Yang, Ting
Wang, Hongyu
Dai, Haiyue
Hui, Juan
Zhang, Jintong
Li, Juan
Cui, Guimei
Wang, Juan
Mu, Junlin
Zhang, Zhaohui
author_facet Yang, Ting
Wang, Hongyu
Dai, Haiyue
Hui, Juan
Zhang, Jintong
Li, Juan
Cui, Guimei
Wang, Juan
Mu, Junlin
Zhang, Zhaohui
author_sort Yang, Ting
collection PubMed
description BACKGROUND: Functional near-infrared spectroscopy (fNIRS) identifies neurophysiological differences between psychiatric disorders by assessing cortical hemodynamic function. Few trials have studied differences in brain functional activity between first-episode medication-naïve depression patients (FMD) and recurrent major depression (RMD). We aimed to determine the differences between FMD and RMD in oxygenated hemoglobin concentration ([oxy-Hb]), and to investigate the correlation between frontotemporal cortex activation and clinical symptoms. METHODS: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance. RESULTS: Both patient groups performed poorly during the VFT task compared with HC (FDR p < 0.05), but there was no significant difference between the two patient groups. Analysis of variance showed that mean [oxy-Hb] activation was lower in both the frontal and temporal lobes in the MDD group compared with HCs (FDR p < 0.05). Additionally, patients with RMD had a significantly lower hemodynamic response in the right dorsolateral prefrontal cortex (DLPFC) and dorsal frontal pole cortex (DFPC) than patients with FMD (FDR p < 0.05). No significant correlation was found between changes in mean [oxy-Hb] and either medical history or clinical symptoms (FDR p < 0.05). CONCLUSION: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2100043432.
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spelling pubmed-101263262023-04-26 The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task Yang, Ting Wang, Hongyu Dai, Haiyue Hui, Juan Zhang, Jintong Li, Juan Cui, Guimei Wang, Juan Mu, Junlin Zhang, Zhaohui Front Psychiatry Psychiatry BACKGROUND: Functional near-infrared spectroscopy (fNIRS) identifies neurophysiological differences between psychiatric disorders by assessing cortical hemodynamic function. Few trials have studied differences in brain functional activity between first-episode medication-naïve depression patients (FMD) and recurrent major depression (RMD). We aimed to determine the differences between FMD and RMD in oxygenated hemoglobin concentration ([oxy-Hb]), and to investigate the correlation between frontotemporal cortex activation and clinical symptoms. METHODS: We recruited 40 patients with FMD, 53 with RMD, and 38 healthy controls (HCs) from May 2021 to April 2022. Symptom severity was assessed with the 24-item Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A). A 52-channel fNIRS measured changes in [oxy-Hb] during VFT performance. RESULTS: Both patient groups performed poorly during the VFT task compared with HC (FDR p < 0.05), but there was no significant difference between the two patient groups. Analysis of variance showed that mean [oxy-Hb] activation was lower in both the frontal and temporal lobes in the MDD group compared with HCs (FDR p < 0.05). Additionally, patients with RMD had a significantly lower hemodynamic response in the right dorsolateral prefrontal cortex (DLPFC) and dorsal frontal pole cortex (DFPC) than patients with FMD (FDR p < 0.05). No significant correlation was found between changes in mean [oxy-Hb] and either medical history or clinical symptoms (FDR p < 0.05). CONCLUSION: The presence of different neurofunctional activity in some of the same brain regions in FMD and RMD patients implied a link between the level of complexity activation in frontal regions and the stage of MDD. Cognitive impairment may already be present at the beginning of an MDD episode. CLINICAL TRIAL REGISTRATION: www.chictr.org.cn, identifier ChiCTR2100043432. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10126326/ /pubmed/37113544 http://dx.doi.org/10.3389/fpsyt.2023.1132666 Text en Copyright © 2023 Yang, Wang, Dai, Hui, Zhang, Li, Cui, Wang, Mu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Yang, Ting
Wang, Hongyu
Dai, Haiyue
Hui, Juan
Zhang, Jintong
Li, Juan
Cui, Guimei
Wang, Juan
Mu, Junlin
Zhang, Zhaohui
The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title_full The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title_fullStr The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title_full_unstemmed The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title_short The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
title_sort fnirs evaluation of frontal and temporal lobe cortical activation in chinese first-episode medication-naïve and recurrent depression during a verbal fluency task
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126326/
https://www.ncbi.nlm.nih.gov/pubmed/37113544
http://dx.doi.org/10.3389/fpsyt.2023.1132666
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